Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
255-280 (Activation loop from InterPro)
Target domain |
98-377 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
0 structures for P00529
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P00529
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00529 | |||||
No associated diseases with P00529
6 regional properties for P00529
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 98 - 377 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 98 - 369 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class II, conserved site | 262 - 270 | IPR002011 |
| active_site | Tyrosine-protein kinase, active site | 228 - 240 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 104 - 133 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 98 - 369 | IPR020635 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| DTVTSPDITA | IVAVIGAVVL | GLTSLTIIIL | FGFVWHQRWK | SRKPASTGQI | VLVKEDKELA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLRGMAETVG | LANACYAVST | LPSQAEIESL | PAFPRDKLNL | HKLLGSGAFG | EVYEGTALDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LADGSGESRV | AVKTLKRGAT | DQEKSEFLKE | AHLMSKFDHP | HILKLLGVCL | LNEPQYLILE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LMEGGDLLSY | LRGARKQKFQ | SPLLTLTDLL | DICLDICKGC | VYLEKMRFIH | RDLAARNCLV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SEKQYGSCSR | VVKIGDFGLA | RDIYKNDYYR | KRGEGLLPVR | WMAPESLIDG | VFTNHSDVWA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FGVLVWETLT | LGQQPYPGLS | NIEVLHHVRS | GGRLESPNNC | PDDIRDLMTR | CWAQDPHNRP |
| 370 | 380 | 390 | 400 | ||
| TFFYIQHKLQ | EIRHSPLCFS | YFLGDKESVA | PLRIQTAFFQ | PL |