P00518

SS
Gene name
PHKG1 (PHKG)
Protein name
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Names
Phosphorylase kinase subunit gamma-1, Serine/threonine-protein kinase PHKG1
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009297
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

(Annotation from UniProt)
The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains.

Autoinhibitory domains (AIDs)

303-327 (Calmodulin-binding domain N) SS

Target domain

20-288 (Protein kinase domain)

Relief mechanism

Assay

343-367 (Calmodulin-binding domain C) SS

Target domain

20-288 (Protein kinase domain)

Relief mechanism

Assay

Accessory elements

167-189 (Activation loop from InterPro)

Target domain

20-288 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

4 structures for P00518

Entry ID Method Resolution Chain Position Source
1PHK X-ray 220 A A 2-299 PDB
1QL6 X-ray 240 A A 2-299 PDB
2PHK X-ray 260 A A 15-291 PDB
AF-P00518-F1 Predicted AlphaFoldDB

No variants for P00518

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P00518

No associated diseases with P00518

3 regional properties for P00518

Type Name Position InterPro Accession
domain Protein kinase domain 20 - 288 IPR000719
active_site Serine/threonine-protein kinase, active site 146 - 158 IPR008271
binding_site Protein kinase, ATP binding site 26 - 49 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.
skeletal muscle myofibril A myofibril of a skeletal muscle fiber.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.

1 GO annotations of biological process

Name Definition
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTRDAALPGS HSTHGFYENY EPKEILGRGV SSVVRRCIHK PTCKEYAVKI IDVTGGGSFS
70 80 90 100 110 120
AEEVQELREA TLKEVDILRK VSGHPNIIQL KDTYETNTFF FLVFDLMKKG ELFDYLTEKV
130 140 150 160 170 180
TLSEKETRKI MRALLEVICA LHKLNIVHRD LKPENILLDD DMNIKLTDFG FSCQLDPGEK
190 200 210 220 230 240
LREVCGTPSY LAPEIIECSM NDNHPGYGKE VDMWSTGVIM YTLLAGSPPF WHRKQMLMLR
250 260 270 280 290 300
MIMSGNYQFG SPEWDDYSDT VKDLVSRFLV VQPQKRYTAE EALAHPFFQQ YVVEEVRHFS
310 320 330 340 350 360
PRGKFKVICL TVLASVRIYY QYRRVKPVTR EIVIRDPYAL RPLRRLIDAY AFRIYGHWVK
370 380
KGQQQNRAAL FENTPKAVLF SLAEDDY