P00472
Gene name |
ecoRIM |
Protein name |
Type II methyltransferase M.EcoRI |
Names |
M.EcoRI, Adenine-specific methyltransferase EcoRI, Modification methylase EcoRI |
Species |
Escherichia coli |
KEGG Pathway |
|
EC number |
2.1.1.72: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P00472
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P00472-F1 | Predicted | AlphaFoldDB |
No variants for P00472
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P00472 | |||||
No associated diseases with P00472
1 regional properties for P00472
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | DNA methylase, N-6 adenine-specific, conserved site | 137 - 143 | IPR002052 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.72 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| site-specific DNA-methyltransferase (adenine-specific) activity | Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA restriction-modification system | A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARNATNKLL | HKAKKSKSDE | FYTQYCDIEN | ELQYYREHFS | DKVVYCNCDD | PRVSNFFKYF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVNFDNLGLK | KLIASCYVEN | KEGFSSSEAA | KNGFYYEYHK | ENGKKLVFDD | ISVSSFCGDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFRSSESIDL | LKKSDIVVTN | PPFSLFREYL | DQLIKYDKKF | LIIANVNSIT | YKEVFNLIKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKIWLGVHLG | RGVSGFIVPE | HYELYGTEAR | IDSNGNRIIS | PNNCLWLTNL | DVFIRHKDLP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTRKYFGNES | SYPKYDNYDA | INVNKTKDIP | LDYNGVMGVP | ITFLHKFNPE | QFELIKFRKG |
| 310 | 320 | ||||
| VDEKDLSING | KCPYFRILIK | NKRLQK |