P00448

PR
Gene name
sodA (b3908, JW3879)
Protein name
Superoxide dismutase [Mn]
Names
MnSOD
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3908
EC number
1.15.1.1: Acting on superoxide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P00448

Entry ID Method Resolution Chain Position Source
1D5N X-ray 155 A A/B/C/D 2-206 PDB
1EN4 X-ray 200 A A/B/C/D 2-206 PDB
1EN5 X-ray 230 A A/B/C/D 2-206 PDB
1EN6 X-ray 200 A A/B/C/D 2-206 PDB
1I08 X-ray 220 A A/B/C/D 2-206 PDB
1I0H X-ray 135 A A/B 2-206 PDB
1IX9 X-ray 090 A A/B 2-206 PDB
1IXB X-ray 090 A A/B 2-206 PDB
1MMM X-ray 220 A A/B 2-206 PDB
1VEW X-ray 210 A A/B/C/D 2-206 PDB
1ZLZ X-ray 155 A A/B 2-206 PDB
3K9S X-ray 155 A A/B/C/D 2-206 PDB
3OT7 X-ray 190 A A/B/C/D 2-206 PDB
AF-P00448-F1 Predicted AlphaFoldDB

1 variants for P00448

Variant ID(s) Position Change Description Diseaes Association Provenance
165 M>L strain: B [UniProt] No

No associated diseases with P00448

No regional properties for P00448

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P00448

Functions

Description
EC Number 1.15.1.1 Acting on superoxide as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

5 GO annotations of molecular function

Name Definition
antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
manganese ion binding Binding to a manganese ion (Mn).
metal ion binding Binding to a metal ion.
superoxide dismutase activity Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.

6 GO annotations of biological process

Name Definition
cellular response to selenium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion.
removal of superoxide radicals Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
response to acidic pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYTLPSLPY AYDALEPHFD KQTMEIHHTK HHQTYVNNAN AALESLPEFA NLPVEELITK
70 80 90 100 110 120
LDQLPADKKT VLRNNAGGHA NHSLFWKGLK KGTTLQGDLK AAIERDFGSV DNFKAEFEKA
130 140 150 160 170 180
AASRFGSGWA WLVLKGDKLA VVSTANQDSP LMGEAISGAS GFPIMGLDVW EHAYYLKFQN
190 200
RRPDYIKEFW NVVNWDEAAA RFAAKK