P00447

PR
Gene name
SOD2 (YHR008C)
Protein name
Superoxide dismutase [Mn], mitochondrial
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YHR008C
EC number
1.15.1.1: Acting on superoxide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P00447

Entry ID Method Resolution Chain Position Source
3BFR X-ray 205 A A 27-233 PDB
3LSU X-ray 190 A A/B/C/D 27-233 PDB
3RN4 X-ray 179 A A 19-233 PDB
4E4E X-ray 188 A A/B/C/D 27-233 PDB
4F6E X-ray 160 A A/B/C/D 28-233 PDB
AF-P00447-F1 Predicted AlphaFoldDB

3 variants for P00447

Variant ID(s) Position Change Description Diseaes Association Provenance
s08-123379 69 D>E No SGRP
s08-123315 91 I>V No SGRP
s08-123181 135 E>D No SGRP

No associated diseases with P00447

3 regional properties for P00447

Type Name Position InterPro Accession
domain Manganese/iron superoxide dismutase, N-terminal 29 - 115 IPR019831
domain Manganese/iron superoxide dismutase, C-terminal 125 - 227 IPR019832
binding_site Manganese/iron superoxide dismutase, binding site 194 - 201 IPR019833

Functions

Description
EC Number 1.15.1.1 Acting on superoxide as acceptor
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
manganese ion binding Binding to a manganese ion (Mn).
superoxide dismutase activity Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.

1 GO annotations of biological process

Name Definition
reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFAKTAAANL TKKGGLSLLS TTARRTKVTL PDLKWDFGAL EPYISGQINE LHYTKHHQTY
70 80 90 100 110 120
VNGFNTAVDQ FQELSDLLAK EPSPANARKM IAIQQNIKFH GGGFTNHCLF WENLAPESQG
130 140 150 160 170 180
GGEPPTGALA KAIDEQFGSL DELIKLTNTK LAGVQGSGWA FIVKNLSNGG KLDVVQTYNQ
190 200 210 220 230
DTVTGPLVPL VAIDAWEHAY YLQYQNKKAD YFKAIWNVVN WKEASRRFDA GKI