P00370

PR
Gene name
gdhA
Protein name
NADP-specific glutamate dehydrogenase
Names
NADP-GDH
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1761
EC number
1.4.1.4: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P00370

Entry ID Method Resolution Chain Position Source
2YFH X-ray 269 A A/B/C/D/E/F 202-405 PDB
3SBO X-ray 320 A A/B/C/D/E/F 1-447 PDB
4BHT X-ray 250 A A/B/C/D/E/F 1-447 PDB
AF-P00370-F1 Predicted AlphaFoldDB

No variants for P00370

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P00370

No associated diseases with P00370

4 regional properties for P00370

Type Name Position InterPro Accession
domain Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal 202 - 445 IPR006096
domain Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain 57 - 184 IPR006097
active_site Leu/Phe/Val dehydrogenases active site 122 - 135 IPR033524
domain NAD(P) binding domain of glutamate dehydrogenase 195 - 446 IPR033922

Functions

Description
EC Number 1.4.1.4 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
glutamate dehydrogenase complex A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies.

2 GO annotations of molecular function

Name Definition
glutamate dehydrogenase (NADP+) activity Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
guanosine tetraphosphate binding Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.

2 GO annotations of biological process

Name Definition
glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQTYSLESF LNHVQKRDPN QTEFAQAVRE VMTTLWPFLE QNPKYRQMSL LERLVEPERV
70 80 90 100 110 120
IQFRVVWVDD RNQIQVNRAW RVQFSSAIGP YKGGMRFHPS VNLSILKFLG FEQTFKNALT
130 140 150 160 170 180
TLPMGGGKGG SDFDPKGKSE GEVMRFCQAL MTELYRHLGA DTDVPAGDIG VGGREVGFMA
190 200 210 220 230 240
GMMKKLSNNT ACVFTGKGLS FGGSLIRPEA TGYGLVYFTE AMLKRHGMGF EGMRVSVSGS
250 260 270 280 290 300
GNVAQYAIEK AMEFGARVIT ASDSSGTVVD ESGFTKEKLA RLIEIKASRD GRVADYAKEF
310 320 330 340 350 360
GLVYLEGQQP WSLPVDIALP CATQNELDVD AAHQLIANGV KAVAEGANMP TTIEATELFQ
370 380 390 400 410 420
QAGVLFAPGK AANAGGVATS GLEMAQNAAR LGWKAEKVDA RLHHIMLDIH HACVEHGGEG
430 440
EQTNYVQGAN IAGFVKVADA MLAQGVI