P00341

PR
Gene name
ldha
Protein name
L-lactate dehydrogenase A chain
Names
LDH-A, LDH-M
Species
Squalus acanthias (Spiny dogfish)
KEGG Pathway
EC number
1.1.1.27: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P00341

Entry ID Method Resolution Chain Position Source
1LDM X-ray 210 A A 2-333 PDB
3LDH X-ray 300 A A 4-333 PDB
6LDH X-ray 200 A A 2-333 PDB
8LDH X-ray 280 A A 2-333 PDB
AF-P00341-F1 Predicted AlphaFoldDB

No variants for P00341

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P00341

No associated diseases with P00341

3 regional properties for P00341

Type Name Position InterPro Accession
domain Lactate/malate dehydrogenase, N-terminal 23 - 161 IPR001236
active_site L-lactate dehydrogenase, active site 191 - 197 IPR018177
domain Lactate/malate dehydrogenase, C-terminal 165 - 328 IPR022383

Functions

Description
EC Number 1.1.1.27 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATLKDKLIG HLATSQEPRS YNKITVVGVG AVGMACAISI LMKDLADEVA LVDVMEDKLK
70 80 90 100 110 120
GEMMDLQHGS LFLHTAKIVS GKDYSVSAGS KLVVITAGAR QQEGESRLNL VQRNVNIFKF
130 140 150 160 170 180
IIPDIVKHSP DCIILVVSNP VDVLTYVAWK LSGLPMHRII GSGCNLDSAR FRYLMGERLG
190 200 210 220 230 240
VHSSSCHGWV IGEHGDSSVP VWSGMNVAGV SLKELHPELG TDKDKENWKK LHKDVVDSAY
250 260 270 280 290 300
EVIKLKGYTS WAIGLSVADL AETIMKNLCR VHPVSTMVKD FYGIKNDVFL SLPCVLDNHG
310 320 330
ISNIVKMKLK PDEEQQLQKS ATTLWDIQKD LKF