O97572

PR
Gene name
RAB7A (RAB7)
Protein name
Ras-related protein Rab-7a
Names
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008682
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

136-207 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O97572

Entry ID Method Resolution Chain Position Source
AF-O97572-F1 Predicted AlphaFoldDB

No variants for O97572

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O97572

No associated diseases with O97572

1 regional properties for O97572

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 10 - 169 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasmic vesicle, phagosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Melanosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Lipid droplet
  • Endosome membrane
  • Cytoplasmic vesicle
  • Mitochondrion membrane ; Peripheral membrane protein
  • Colocalizes with OSBPL1A at the late endosome
  • Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts
  • Recruited to phagosomes containing S
  • aureus or Mycobacterium
  • Lipid droplet localization is increased upon ADRB2 stimulation
  • Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
autophagosome membrane The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of lysosome membrane The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
late endosome membrane The lipid bilayer surrounding a late endosome.
lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
melanosome membrane The lipid bilayer surrounding a melanosome.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.

2 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GTP binding Binding to GTP, guanosine triphosphate.

6 GO annotations of biological process

Name Definition
early endosome to late endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
endosome to plasma membrane protein transport The directed movement of proteins from the endosome to the plasma membrane in transport vesicles.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipophagy The selective autophagy process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions.
phagosome acidification Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.
phagosome-lysosome fusion The creation of a phagolysosome from a phagosome and a lysosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ
70 80 90 100 110 120
IWDTAGQERF QSLSVAFYRG ADCCVLVFDV TAPNTFKTLD SWRLEFLIQA SPRDPENFPF
130 140 150 160 170 180
VVLGNKIDLE NRQVATKRAQ AWSYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV
190 200
ELYNEFPEPM KLDKNDRAKT SAESCSC