O96567

PR
Gene name
Ddc
Protein name
Aromatic-L-amino-acid decarboxylase
Names
AADC, DOPA decarboxylase, DDC
Species
Drosophila simulans (Fruit fly)
KEGG Pathway
EC number
4.1.1.28: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O96567

Entry ID Method Resolution Chain Position Source
AF-O96567-F1 Predicted AlphaFoldDB

No variants for O96567

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O96567

No associated diseases with O96567

1 regional properties for O96567

Type Name Position InterPro Accession
binding_site Pyridoxal-phosphate binding site 330 - 351 IPR021115

Functions

Description
EC Number 4.1.1.28 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
5-hydroxy-L-tryptophan decarboxylase activity Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin.
L-dopa decarboxylase activity Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

11 GO annotations of biological process

Name Definition
adult chitin-containing cuticle pigmentation Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster.
anesthesia-resistant memory The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.
dopamine biosynthetic process from tyrosine The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine.
long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
regulation of adult chitin-containing cuticle pigmentation Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
serotonin biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
thermosensory behavior Behavior that is dependent upon the sensation of temperature.
thermotaxis The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
wing disc development Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSHIPISNTI PPKQTDGNGK ANISPDKLDP KVSIDMEAPE FKDFAKTMVD FIAEYLENIR
70 80 90 100 110 120
DRRVLPEVKP GYLKPLIPDA APEKPEKWQD VMQDIERVIM PGVTHWHSPK FHAYFPTANS
130 140 150 160 170 180
YPAIVADMLS GAIACIGFTW IASPACTELE VVMMDWLGKM LELPAEFLVC SGGKGGGVIQ
190 200 210 220 230 240
GTASESTLVA LLGAKAKKLK EVKELHPEWD EHTILGKLVG YCSDQAHSSV ERAGLLGGVK
250 260 270 280 290 300
LRSVQSENHR MRGAALEKAI EQDLAEGLIP FYAVVTLGTT NSCAFDYLDE CGPVGNKHNL
310 320 330 340 350 360
WIHVDAAYAG SAFICPEYRH LMKGIESADS FNFNPHKWML VNFDCSAMWL KDPSWVVNAF
370 380 390 400 410 420
NVDPLYLKHD MQGSAPDYRH WQIPLGRRFR ALKLWFVLRL YGVENLQAHI RRHCNFAKQF
430 440 450 460 470 480
GDLCVADSRF ELAAEINMGL VCFRLKGSNE RNEALLKRIN GRGHIHLVPA KIKDVYFLRM
490 500
AICSRFTQSE DMEYSWKEVS AAADEMEQEQ