AiPD: Autoinhibited Protein Database

O95707

Gene name	POP4 (RPP29)
Protein name	Ribonuclease P protein subunit p29
Names	hPOP4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10775
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-48 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for O95707

Entry ID	Method	Resolution	Chain	Position	Source
6AHR	EM	392 A	D	1-220	PDB
6AHU	EM	366 A	D	1-220	PDB
AF-O95707-F1	Predicted				AlphaFoldDB

224 variants for O95707

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs560619277 CA405146146	2	K>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9351039 rs560619277	2	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9351041 rs150671362	2	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1478255708 CA405146153	2	K>R		No	ClinGen gnomAD
rs1478255708 CA405146155	2	K>T		No	ClinGen gnomAD
rs780885172 CA306796596	3	S>C		No	ClinGen ExAC TOPMed gnomAD
rs780885172 CA9351042	3	S>G		No	ClinGen ExAC TOPMed gnomAD
CA9351091 rs562546233	3	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405146185 rs780885172	3	S>R		No	ClinGen ExAC TOPMed gnomAD
CA306798297 rs368711270	7	H>R		No	ClinGen ESP
CA9351094 rs748635817	9	L>S		No	ClinGen ExAC gnomAD
CA405147488 rs1295198656	11	Q>R		No	ClinGen gnomAD
rs561827225 CA9351095	13	E>V		No	ClinGen 1000Genomes ExAC gnomAD
rs140893351 CA9351097	14	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA9351096 rs140893351	14	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs776378364 CA9351099	16	D>H		No	ClinGen ExAC gnomAD
rs144806266 CA9351101	18	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs144806266 CA405147566	18	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA306798365 rs907137050	20	Q>R		No	ClinGen gnomAD
rs191569878 CA9351128	21	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1568294329 CA405147756	22	S>A		No	ClinGen Ensembl
TCGA novel	22	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355312242 CA405147771	24	A>V		No	ClinGen gnomAD
rs1485076676 CA405147775	25	Q>P		No	ClinGen TOPMed
CA405147780 rs1316634069	26	R>G		No	ClinGen TOPMed gnomAD
CA405147781 rs371815864	26	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA9351132 rs371815864	26	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9351130 rs1316634069	26	R>W		No	ClinGen TOPMed gnomAD
rs1245290223 CA405147787	27	A>D		No	ClinGen TOPMed
rs758794017 CA9351135	28	E>G		No	ClinGen ExAC gnomAD
rs1047470546 CA306799699	28	E>K		No	ClinGen TOPMed gnomAD
CA405147795 rs1330913474	29	A>T		No	ClinGen TOPMed
rs1156752102 CA405147799	29	A>V		No	ClinGen gnomAD
rs1421664988 CA405147809	31	V>M		No	ClinGen TOPMed gnomAD
rs780819724 CA9351139	33	A>D		No	ClinGen ExAC gnomAD
CA405147824 rs780819724	33	A>G		No	ClinGen ExAC gnomAD
CA9351138 rs756831070	33	A>T		No	ClinGen ExAC TOPMed gnomAD
CA405147829 rs547325169	34	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs547325169 CA9351140	34	F>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769536040 CA9351141	36	K>R		No	ClinGen ExAC TOPMed gnomAD
rs774977285 CA9351142	37	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs749115573 CA9351143	37	R>H		No	ClinGen ExAC TOPMed gnomAD
CA405147854 rs1379732564	38	S>N		No	ClinGen gnomAD
CA9351144 rs565503123	39	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs565503123 CA405147861	39	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9351147 rs767356797	40	P>L		No	ClinGen ExAC gnomAD
CA9351146 rs761673906	40	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	41	R>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776833922 CA9351148	41	R>C		No	ClinGen ExAC gnomAD
rs369766266 CA9351149	41	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs369766266 CA306799756	41	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs752810458 CA9351151	42	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1469678594 CA405147880	43	S>N		No	ClinGen TOPMed
rs1440268826 CA405147884	43	S>R		No	ClinGen gnomAD
rs758843443 CA9351152	44	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1192872078 CA405147885	44	P>T		No	ClinGen gnomAD
CA405147895 rs1232619188	45	Q>R		No	ClinGen TOPMed
CA9351154 rs751965777	46	A>V		No	ClinGen ExAC gnomAD
CA9351155 rs372777322	47	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9351156 rs372777322	47	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs557496741 CA9351157	47	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779780512 CA9351159	48	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1303242887 CA405147913	49	D>N		No	ClinGen TOPMed gnomAD
rs556692615 CA9351162	50	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1599486024 CA405147921	50	Q>K		No	ClinGen Ensembl
CA9351163 rs747928353	51	L>V		No	ClinGen ExAC gnomAD
rs1196317823 CA405147942	53	R>C		No	ClinGen TOPMed gnomAD
CA405147945 rs1259772679	53	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1457998230 CA405147947	54	K>E		No	ClinGen gnomAD
CA9351165 rs772099926	54	K>T		No	ClinGen ExAC TOPMed gnomAD
CA9351167 rs759679720	55	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA405147960 rs1599486051	56	V>G		No	ClinGen Ensembl
CA9351169 rs775855654	56	V>M		No	ClinGen ExAC gnomAD
CA405147968 rs1599486057	57	V>G		No	ClinGen Ensembl
CA306799913 rs998906348	59	E>G		No	ClinGen Ensembl
rs1599486059 CA405147984	60	Y>D		No	ClinGen Ensembl
rs764397495 CA9351171	60	Y>F		No	ClinGen ExAC gnomAD
CA9351172 rs752018779	61	F>L		No	ClinGen ExAC TOPMed gnomAD
CA405147994 rs752018779	61	F>V		No	ClinGen ExAC TOPMed gnomAD
CA9351173 rs377019351	62	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA306799920 rs77017418	62	T>P		No	ClinGen TOPMed gnomAD
CA9351174 rs768101003	63	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9351175 rs750848621	63	R>H		No	ClinGen ExAC TOPMed gnomAD
CA405148016 rs750848621	63	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9351177 rs779367232	64	H>Q		No	ClinGen ExAC gnomAD
CA405148026 rs1325298849	64	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	64	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371486003 CA9351178	66	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371486003 CA9351179	66	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs552871765 CA9351180	66	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9351181 rs552871765	66	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	68	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405148078 rs1312082144	69	K>E		No	ClinGen gnomAD
rs777777758 CA9351185	69	K>N		No	ClinGen ExAC gnomAD
CA405148104 rs1487971410	71	K>*		No	ClinGen gnomAD
rs770896138 CA9351187	71	K>M		No	ClinGen ExAC gnomAD
CA405148126 rs1478388260	73	A>T		No	ClinGen gnomAD
TCGA novel	73	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1164637022 CA405148136	74	K>R		No	ClinGen gnomAD
CA9351192 rs769038402	75	G>A		No	ClinGen ExAC TOPMed gnomAD
CA9351193 rs769038402	75	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1599486135 CA405148157	78	A>T		No	ClinGen Ensembl
rs1383619932 CA405148165	79	R>K		No	ClinGen gnomAD
CA9351196 rs201177789	80	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405148177 rs1347264681	81	R>G		No	ClinGen TOPMed
CA9351198 rs761155586	81	R>K		No	ClinGen ExAC gnomAD
rs1413982558 CA405148182	81	R>S		No	ClinGen gnomAD
TCGA novel	83	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs147388913 CA9351200	85	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs766860828 CA9351199	85	R>W		No	ClinGen ExAC TOPMed gnomAD
rs915944191 CA306800035	88	D>H		No	ClinGen Ensembl
rs778554784 CA9351202	89	I>V		No	ClinGen ExAC TOPMed gnomAD
rs565176404 CA9351203	91	P>A		No	ClinGen 1000Genomes ExAC
CA405148244 rs1192672337	91	P>R		No	ClinGen gnomAD
CA306762599 rs907947974	96	Y>C		No	ClinGen Ensembl
rs1360530644 CA405139479	100	L>R		No	ClinGen gnomAD
CA9351228 rs139555241	101	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405139495 rs1377822526	103	H>R		No	ClinGen gnomAD
rs773456462 CA9351231	104	E>D		No	ClinGen ExAC gnomAD
CA306762623 rs1040370347	104	E>K		No	ClinGen Ensembl
CA405139518 rs1299521054	106	W>C		No	ClinGen TOPMed gnomAD
rs901882069 CA306762630	107	K>E		No	ClinGen TOPMed
rs747367943 CA9351232	108	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	108	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9351234 rs771224240	110	I>F		No	ClinGen ExAC TOPMed gnomAD
CA9351233 rs771224240	110	I>L		No	ClinGen ExAC TOPMed gnomAD
CA405139543 rs1568294971	110	I>N		No	ClinGen Ensembl
TCGA novel	110	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405139542 rs771224240	110	I>V		No	ClinGen ExAC TOPMed gnomAD
rs77418580 CA306762651	112	D>G		No	ClinGen Ensembl
rs897423885 CA306762659	114	C>F		No	ClinGen TOPMed gnomAD
CA405139569 rs897423885	114	C>Y		No	ClinGen TOPMed gnomAD
CA9351237 rs774910255	115	S>T		No	ClinGen ExAC gnomAD
rs1442406188 CA405139610	120	D>G		No	ClinGen TOPMed
rs1283237729 CA405139608	120	D>N		No	ClinGen TOPMed
rs201440100 CA9351242	121	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405139618 rs201440100	121	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs11556818 CA306762880	122	Q>H		No	ClinGen Ensembl
rs752887866 CA306762869	122	Q>K		No	ClinGen gnomAD
CA405139639 rs1338666899	123	P>L		No	ClinGen gnomAD
rs1297890597 CA405139637	123	P>S		No	ClinGen gnomAD
CA405139642 rs1402295237	124	Q>E		No	ClinGen gnomAD
CA9351263 rs766261948	124	Q>P		No	ClinGen ExAC gnomAD
rs555100162 CA9351264	125	M>V		No	ClinGen ExAC gnomAD
rs1283476222 CA405139671	128	A>P		No	ClinGen TOPMed
CA405139673 rs1283476222	128	A>T		No	ClinGen TOPMed
rs553997230 CA306762895	128	A>V		No	ClinGen 1000Genomes
rs908974563 CA306762904	129	K>E		No	ClinGen TOPMed
rs758409161 CA9351265	129	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs777972860 CA9351266	130	L>F		No	ClinGen ExAC
rs1292634049 CA405139684	130	L>P		No	ClinGen gnomAD
CA405139688 rs1384857147	131	L>V		No	ClinGen TOPMed
rs781359325 CA9351269	134	D>V		No	ClinGen ExAC gnomAD
CA306762939 rs936934863	137	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	138	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1435632355 CA405139741	139	I>V		No	ClinGen TOPMed
CA405139751 rs1471655673	140	I>T		No	ClinGen gnomAD
CA9351286 rs190122547	142	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1045558399 CA306764457	143	T>A		No	ClinGen Ensembl
CA9351287 rs781414590	143	T>K		No	ClinGen ExAC gnomAD
TCGA novel	145	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405140080 rs1378551030	147	C>Y		No	ClinGen gnomAD
CA306764488 rs928496141	148	P>L		No	ClinGen gnomAD
CA405140085 rs1247649850	148	P>T		No	ClinGen TOPMed
TCGA novel	149	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	150	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1413171084 CA405140117	153	I>V		No	ClinGen gnomAD
CA405140138 rs1446705091	156	I>N		No	ClinGen gnomAD
CA9351291 rs199914869	158	L>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405140154 rs1240589776	159	Q>*		No	ClinGen TOPMed
TCGA novel	160	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs891562743 CA306764527	162	K>Q		No	ClinGen TOPMed
rs1441610311 CA405140183	163	H>Y		No	ClinGen TOPMed
rs145445007 CA306764540	164	I>F		No	ClinGen ESP
TCGA novel	167	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1342407767 CA405140220	168	I>V		No	ClinGen gnomAD
CA9351294 rs769257774	170	K>R		No	ClinGen ExAC gnomAD
rs547007300 CA9351297	173	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9351299 rs61731483	173	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61731483 CA9351298	173	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773330218 CA9351334	177	I>F		No	ClinGen ExAC TOPMed gnomAD
CA405140293 rs1263599642	177	I>M		No	ClinGen TOPMed gnomAD
CA405140294 rs1427792184	178	P>S		No	ClinGen gnomAD
rs1354416815 CA405140304	179	K>R		No	ClinGen TOPMed gnomAD
rs373272239 CA306765900	180	L>P		No	ClinGen ESP TOPMed
CA405140325 rs184488449	182	C>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9351335 rs760642859	182	C>R		No	ClinGen ExAC gnomAD
rs1264302287 CA405140329	183	V>A		No	ClinGen gnomAD
rs753961498 CA306765917	183	V>L		No	ClinGen ExAC gnomAD
CA9351337 rs753961498	183	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1358269789 CA405140351	187	E>*		No	ClinGen gnomAD
rs1187528012 CA405140364	188	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1187528012 CA405140363	188	T>S		No	ClinGen gnomAD
CA405140369 rs1299878820	189	D>E		No	ClinGen gnomAD
rs13767 CA9351341	189	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1163696278 CA405140367	189	D>V		No	ClinGen gnomAD
rs13767 CA9351342	189	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759019897 CA405140386	192	I>F		No	ClinGen ExAC TOPMed gnomAD
rs199910211 CA9351344	192	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9351343 rs759019897	192	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1290017126 CA405140391	193	S>P		No	ClinGen TOPMed
CA9351348 rs370479191	197	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs370479191 CA9351349	197	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA405140441 rs1315860307	200	F>V		No	ClinGen gnomAD
CA9351351 rs775330538	201	Q>*		No	ClinGen ExAC gnomAD
rs536828056 CA306766017	203	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs536828056 CA9351352	203	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1262696040 CA405140461	203	R>W	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1425087395 CA405140476	205	S>R		No	ClinGen TOPMed
CA405140486 rs1254453303	207	R>Q		No	ClinGen TOPMed gnomAD
CA9351353 rs768627869	207	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9351354 rs138123473	209	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs201670827 CA306766031	211	K>N		No	ClinGen Ensembl
CA405140521 CA9351356 rs770846548	212	F>L		No	ClinGen ExAC gnomAD
rs1379173414 CA405140518	212	F>S		No	ClinGen gnomAD
CA405140527 rs1160921456	213	K>T		No	ClinGen gnomAD
CA9351357 rs143408535	214	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs759908705 CA9351358	214	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1248991827 CA405140540	215	K>N		No	ClinGen gnomAD
CA405140538 rs1404034451	215	K>R		No	ClinGen gnomAD
rs377056786 CA9351360	216	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9351362 rs74712490	217	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1393952224 CA405140556	218	I>T		No	ClinGen gnomAD
rs34601920 CA9351364	219	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with O95707

No regional properties for O95707

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O95707

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
multimeric ribonuclease P complex	A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
ribonuclease MRP complex	A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.
ribonuclease P complex	A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.

2 GO annotations of molecular function

Name	Definition
ribonuclease P activity	Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor.
ribonuclease P RNA binding	Binding to RNA subunit of ribonuclease P.

2 GO annotations of biological process

Name	Definition
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
tRNA 5'-leader removal	Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38336	POP4	RNases MRP/P 32.9 kDa subunit	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR

10	20	30	40	50	60
MKSVIYHALS	QKEANDSDVQ	PSGAQRAEAF	VRAFLKRSTP	RMSPQAREDQ	LQRKAVVLEY
70	80	90	100	110	120
FTRHKRKEKK	KKAKGLSARQ	RRELRLFDIK	PEQQRYSLFL	PLHELWKQYI	RDLCSGLKPD
130	140	150	160	170	180
TQPQMIQAKL	LKADLHGAII	SVTKSKCPSY	VGITGILLQE	TKHIFKIITK	EDRLKVIPKL
190	200	210
NCVFTVETDG	FISYIYGSKF	QLRSSERSAK	KFKAKGTIDL