AiPD: Autoinhibited Protein Database

O94864

Gene name	SUPT7L (KIAA0764)
Protein name	STAGA complex 65 subunit gamma
Names	Adenocarcinoma antigen ART1, SPTF-associated factor 65 gamma, STAF65gamma, Suppressor of Ty 7-like
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9913
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

66-143 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

66-143 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for O94864

Entry ID	Method	Resolution	Chain	Position	Source
7KTR	EM	293 A	D	51-414	PDB
7KTS	EM	1909 A	D	1-414	PDB
8H7G	EM	370 A	I	1-414	PDB
AF-O94864-F1	Predicted				AlphaFoldDB

314 variants for O94864

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs373802691 CA1584785	2	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA346385100 rs1305041585	4	Q>*		No	ClinGen TOPMed gnomAD
CA346385103 rs1305041585	4	Q>K		No	ClinGen TOPMed gnomAD
CA1584769 rs372331209	5	R>S		No	ClinGen ESP ExAC TOPMed
CA346384602 rs1316649428	6	Y>C		No	ClinGen Ensembl
rs759418062 CA1584768	6	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1403895886 CA346384584	7	W>C		No	ClinGen TOPMed
CA346384592 rs1396747078	7	W>G		No	ClinGen gnomAD
CA346384580 rs1302941143	8	G>R		No	ClinGen gnomAD
CA346384556 rs1171684598	9	E>D		No	ClinGen gnomAD
CA1584766 rs771243712	11	P>A		No	ClinGen ExAC gnomAD
CA44533374 rs919943998	11	P>L		No	ClinGen TOPMed
rs368383395 CA44533357	12	I>L		No	ClinGen ESP TOPMed
rs1572982267 CA346384508	14	S>P		No	ClinGen Ensembl
CA346384463 rs1439195324	16	Q>P		No	ClinGen TOPMed
CA44533348 rs1038303297	17	T>A		No	ClinGen TOPMed gnomAD
rs777913728 CA1584763	18	N>K		No	ClinGen ExAC gnomAD
CA1584762 rs769815831	22	F>L		No	ClinGen ExAC TOPMed gnomAD
CA346384376 rs1282646743	23	D>H		No	ClinGen gnomAD
CA346384373 rs1282646743	23	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA346384337 rs1279638437	26	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs200959399 CA1584761	27	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781692578 CA346384303	28	E>D		No	ClinGen ExAC TOPMed
rs1208936908 CA346384308	28	E>G		No	ClinGen TOPMed
CA1584759 rs755452936	29	F>L		No	ClinGen ExAC gnomAD
rs1298760567 COSM387009 CA346384282	30	R>C	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
COSM1407514 rs752015900 CA1584758	30	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA346384206 rs1572982142	36	D>A		No	ClinGen Ensembl
CA346384162 rs1572982094	40	H>P		No	ClinGen Ensembl
rs1372258856 CA346384138	41	Q>H		No	ClinGen gnomAD
CA346384132 rs1396035748	42	P>S		No	ClinGen gnomAD
CA1584754 rs753378560	44	A>D		No	ClinGen ExAC gnomAD
CA44533324 rs903144517	46	K>R		No	ClinGen Ensembl
rs548044329 CA1584753	47	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1020303374 CA44533322	47	P>S		No	ClinGen Ensembl
CA346384040 rs1390751342	49	P>S		No	ClinGen gnomAD
TCGA novel	51	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs971288974 CA44533318	52	M>T		No	ClinGen TOPMed
rs767613710 CA1584750	52	M>V		No	ClinGen ExAC TOPMed gnomAD
CA346383961 rs1572981979	55	I>T		No	ClinGen Ensembl
CA346383967 rs1192740869	55	I>V		No	ClinGen gnomAD
TCGA novel	56	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346383909 rs1443271758	60	C>R		No	ClinGen gnomAD
CA1584749 rs759379847	61	S>N		No	ClinGen ExAC
CA346383871 rs1572981949	63	T>P		No	ClinGen Ensembl
rs1400919268 CA346383859	64	I>F		No	ClinGen gnomAD
CA44533315 rs913043421	65	H>R		No	ClinGen TOPMed
CA346383842 rs1259682557	65	H>Y		No	ClinGen gnomAD
CA346383832 rs1485609744	66	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1337857525 CA346383777	71	Q>E		No	ClinGen TOPMed gnomAD
rs1296838986 CA346383761	72	H>Y		No	ClinGen TOPMed
CA346383742 rs1360470770	73	N>S		No	ClinGen TOPMed
CA1584745 rs773381394	74	R>*		No	ClinGen ExAC TOPMed gnomAD
CA44533298 rs773381394	74	R>G		No	ClinGen ExAC TOPMed gnomAD
rs114487538 CA1584744	74	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748274586 CA1584743	75	R>C		No	ClinGen ExAC gnomAD
CA1584742 rs184249965	75	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1413662476 CA346383715	76	L>V		No	ClinGen gnomAD
CA1584740 rs367572958	77	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs747404460 CA1584739	80	I>V		No	ClinGen ExAC gnomAD
rs1237714896 CA346383636	83	A>T		No	ClinGen TOPMed
CA346383618 rs1240410643	84	Q>R		No	ClinGen Ensembl
CA346383613 rs1185839651	85	A>T		No	ClinGen gnomAD
CA346383578 rs1233892428	87	N>K		No	ClinGen gnomAD
TCGA novel	88	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1436633260 CA346383538	90	Q>L		No	ClinGen gnomAD
TCGA novel	92	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346383504 rs1272711947	93	G>S		No	ClinGen gnomAD
CA1584737 rs201679796	94	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584735 rs777610958	97	E>G		No	ClinGen ExAC gnomAD
CA346383462 rs753562086	97	E>K		No	ClinGen ExAC gnomAD
CA1584736 rs753562086	97	E>Q		No	ClinGen ExAC gnomAD
CA44533269 rs201942828	98	E>D		No	ClinGen Ensembl
CA1584734 rs755809244	99	S>N		No	ClinGen ExAC TOPMed gnomAD
CA346383411 rs1572981703	100	E>D		No	ClinGen Ensembl
CA346383406 rs1280844978	101	P>R		No	ClinGen gnomAD
CA346383401 rs1187058063	102	L>F		No	ClinGen TOPMed
rs1187058063 CA346383403	102	L>I		No	ClinGen TOPMed
rs917490393 CA44533261	103	P>R		No	ClinGen Ensembl
rs1473947426 CA346383395	103	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs531573550 CA1584732	104	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA346383390 rs1335143292	104	S>T		No	ClinGen gnomAD
CA346383374 rs1396895134	106	P>L		No	ClinGen gnomAD
CA1584730 rs751395014	107	G>R		No	ClinGen ExAC gnomAD
CA346383369 rs1380148841	107	G>V		No	ClinGen TOPMed
CA346383366 rs1461180196	108	S>A		No	ClinGen gnomAD
rs191619402 CA1584729	108	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1584728 rs200392709	111	L>F		No	ClinGen ExAC TOPMed gnomAD
CA1584727 rs200392709	111	L>V		No	ClinGen ExAC TOPMed gnomAD
CA346383332 rs1394975657	114	D>Y		No	ClinGen TOPMed
CA346383324 rs776693329	115	L>F		No	ClinGen ExAC gnomAD
CA346383322 rs1203650484	115	L>P		No	ClinGen gnomAD
rs776693329 CA1584724	115	L>V		No	ClinGen ExAC gnomAD
rs1271738934 CA346383310	117	P>L		No	ClinGen gnomAD
CA346383313 rs1341904964	117	P>S		No	ClinGen TOPMed
CA346383305 rs1481956960	118	L>S		No	ClinGen gnomAD
rs775824239 CA1584720	119	D>N		No	ClinGen ExAC TOPMed gnomAD
rs746286777 CA1584718	120	C>F		No	ClinGen ExAC gnomAD
rs1308251419 CA346383293	120	C>G		No	ClinGen TOPMed
rs779408618 CA1584717	121	K>E		No	ClinGen ExAC gnomAD
CA1584716 rs147739348	124	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147739348 CA1584715	124	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370733245 CA1584713	125	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584712 rs751048846	126	P>S		No	ClinGen ExAC gnomAD
CA346383235 rs1399050230	129	I>V		No	ClinGen TOPMed gnomAD
rs201094706 CA1584710	130	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584709 rs201094706	130	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584711 rs766274406	130	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	135	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346383185 rs1558501362	136	S>N		No	ClinGen Ensembl
CA346383177 rs1251500803	137	D>A		No	ClinGen gnomAD
rs764942442 CA1584708	137	D>N		No	ClinGen ExAC gnomAD
CA1584707 rs545468088	140	R>C		No	ClinGen ExAC gnomAD
CA1584706 rs201686280	140	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs765035299 CA1584689	143	G>V		No	ClinGen ExAC gnomAD
rs573239193 CA44532083	146	V>L		No	ClinGen 1000Genomes
rs1380469453 CA346383092	148	E>A		No	ClinGen TOPMed
CA1584688 rs757009850	148	E>D		No	ClinGen ExAC gnomAD
COSM108442 COSM106922 rs141161184 CA44532073	151	W>*	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
COSM108442 rs143153409 COSM106922 CA44532076	151	W>*	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
TCGA novel	151	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346383062 rs1293250499	152	H>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs753603294 CA1584687	153	S>C		No	ClinGen ExAC TOPMed gnomAD
CA1584686 rs764275544	154	C>F		No	ClinGen ExAC gnomAD
TCGA novel	154	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1584684 rs200164884	155	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1584685 rs760941180	155	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1464676847 CA346383040	156	Q>R		No	ClinGen TOPMed
CA346383033 rs1463008586	157	L>P		No	ClinGen gnomAD
rs770187094 CA1584680	158	L>F		No	ClinGen ExAC gnomAD
CA346383018 rs1427522561	159	Y>*		No	ClinGen gnomAD
CA346383024 rs1168833594	159	Y>H		No	ClinGen gnomAD
rs1572977875 CA346383022	159	Y>S		No	ClinGen Ensembl
CA346383013 rs1418157550	160	Q>P		No	ClinGen gnomAD
CA1584679 rs746180181	161	A>E		No	ClinGen ExAC TOPMed gnomAD
rs746180181 CA346383005	161	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1256635606 CA346382128	163	A>S		No	ClinGen TOPMed gnomAD
rs377222033 CA1584678	164	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584676 rs746602273	168	H>D		No	ClinGen ExAC gnomAD
rs770037914 CA1584674	168	H>Q		No	ClinGen ExAC gnomAD
CA346382095 rs1558499755	169	A>T		No	ClinGen Ensembl
CA1584673 rs369425683	169	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584671 rs757169060	170	G>A		No	ClinGen ExAC gnomAD
rs1312166703 CA346382081	171	F>S		No	ClinGen gnomAD
rs753636659 CA1584670	172	D>E		No	ClinGen ExAC TOPMed gnomAD
CA44532014 rs777622585	173	C>G		No	ClinGen ExAC gnomAD
CA1584669 rs777622585	173	C>R		No	ClinGen ExAC gnomAD
rs756296292 CA1584668	173	C>S		No	ClinGen ExAC TOPMed gnomAD
CA44531989 rs748261616	175	N>D		No	ClinGen TOPMed gnomAD
rs767727949 CA1584666	175	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1416495827 CA346382051	176	E>*		No	ClinGen gnomAD
CA1584665 rs200996052	177	S>T		No	ClinGen 1000Genomes ExAC gnomAD
CA1584663 rs751665936	178	V>I		No	ClinGen ExAC gnomAD
CA1584662 rs767051220	180	E>K		No	ClinGen ExAC gnomAD
rs763547158 CA1584661	181	T>I		No	ClinGen ExAC
CA346382018 rs763547158	181	T>N		No	ClinGen ExAC
CA1584660 rs773451475	183	T>I		No	ClinGen ExAC gnomAD
rs770135844 CA1584659	184	D>E		No	ClinGen ExAC gnomAD
rs1254736093 CA346382006	184	D>N		No	ClinGen gnomAD
rs1181920219 CA346382001	184	D>V		No	ClinGen gnomAD
CA346381995 rs1451778445	185	V>A		No	ClinGen TOPMed
CA1584658 rs760263007	187	H>R		No	ClinGen ExAC
CA44531942 rs747562533	191	L>P		No	ClinGen Ensembl
CA1584657 COSM1267046 rs569167167	192	K>T	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs375571980 CA1584656	198	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs375571980 CA1584655	198	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584654 rs778384649	198	R>H		No	ClinGen ExAC TOPMed gnomAD
CA346381892 rs1446419672	201	V>M		No	ClinGen gnomAD
TCGA novel	202	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346381878 rs557391081	203	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA44531924 rs371987223	203	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs371987223 CA1584652	203	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs557391081 CA1584653	203	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1321878256 CA346381872	204	E>G		No	ClinGen TOPMed
rs953733516 CA44531921	205	A>V		No	ClinGen TOPMed gnomAD
CA1584649 rs752894387	206	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs755890924 CA1584650	206	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA346381855 rs1158288387	208	G>R		No	ClinGen TOPMed gnomAD
rs1572977543 CA346381844	209	Q>H		No	ClinGen Ensembl
CA1584648 rs781613860	209	Q>R		No	ClinGen ExAC gnomAD
CA346381839 rs1254620434	210	T>I		No	ClinGen gnomAD
rs368138417 CA1584647	211	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs368138417 CA346381833	211	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584646 rs368138417	211	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1191553159 CA346381836	211	P>T		No	ClinGen gnomAD
rs766498602 CA1584645	213	P>S		No	ClinGen ExAC gnomAD
CA1584644 rs758839917	214	D>E		No	ClinGen ExAC gnomAD
CA346381800 rs201032397 CA1584643	216	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1584642 rs765547884	217	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA346381798 rs765547884	217	E>Q		No	ClinGen ExAC gnomAD
rs1404266669 CA346381788	218	Q>P		No	ClinGen TOPMed
CA44531894 rs879030274	219	V>A		No	ClinGen Ensembl
rs776961728 CA1584641	219	V>I		No	ClinGen ExAC TOPMed gnomAD
rs776961728 CA1584640	219	V>L		No	ClinGen ExAC TOPMed gnomAD
rs188290387 CA1584638	224	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773859319 CA44531886	226	G>A		No	ClinGen ExAC TOPMed gnomAD
rs773859319 CA1584637	226	G>D		No	ClinGen ExAC TOPMed gnomAD
CA346381673 rs1572977414	227	S>R		No	ClinGen Ensembl
rs1051361501 CA44531885	228	V>G		No	ClinGen Ensembl
rs770371850 CA1584636	229	L>R		No	ClinGen ExAC TOPMed gnomAD
CA1584635 rs749207389	233	K>N		No	ClinGen ExAC gnomAD
rs374434548 CA1584633	238	R>C		No	ClinGen ESP ExAC gnomAD
rs374434548 CA1584634	238	R>G		No	ClinGen ESP ExAC gnomAD
CA1584632 rs372248888 COSM295683	238	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs781129599 CA1584631	241	D>E		No	ClinGen ExAC gnomAD
rs1477581171 CA346381477	242	Y>C		No	ClinGen gnomAD
CA346381257 rs1409232919	251	K>N		No	ClinGen TOPMed
rs1442402388	254	S>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA44531263 rs899380851	254	S>P		No	ClinGen TOPMed
rs758523714 CA1584608	255	E>D		No	ClinGen ExAC gnomAD
rs746021382 CA1584607	256	E>D		No	ClinGen ExAC gnomAD
CA44531257 rs1055776416	258	E>V		No	ClinGen TOPMed
TCGA novel	259	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA44531250 rs909218870	260	I>S		No	ClinGen TOPMed gnomAD
rs909218870 CA44531254	260	I>T		No	ClinGen TOPMed gnomAD
CA346381123 rs1572975512	261	V>I		No	ClinGen Ensembl
rs778859365 CA1584606	262	N>S		No	ClinGen ExAC gnomAD
CA1584605 rs757789956	265	K>E		No	ClinGen ExAC TOPMed gnomAD
CA1584604 rs754288302	265	K>T		No	ClinGen ExAC TOPMed gnomAD
rs945413244 CA44531237	266	A>D		No	ClinGen TOPMed
rs929901418 CA44531234	267	T>K		No	ClinGen Ensembl
CA1584603 rs535145831	268	E>A		No	ClinGen 1000Genomes ExAC gnomAD
CA44531226 CA1584601 rs188551129	269	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1584600 rs200121280	270	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1489378385 CA346380978	272	P>T		No	ClinGen gnomAD
CA346380942 rs1170229229	276	K>Q		No	ClinGen gnomAD
CA346380924 rs764592470	277	E>G		No	ClinGen ExAC TOPMed gnomAD
rs764592470 CA1584597	277	E>V		No	ClinGen ExAC TOPMed gnomAD
CA346380874 rs1558498559	281	S>G		No	ClinGen Ensembl
CA1584594 rs377296864	282	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs750367400 CA1584593	287	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1233992692 CA346380772	288	S>T		No	ClinGen gnomAD
rs1184358215 CA346380756	289	E>G		No	ClinGen gnomAD
CA44531200 rs970575929	290	E>*		No	ClinGen TOPMed
rs970575929 CA346380746 COSM1019859	290	E>K	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA346380730 rs1456722764	291	L>V		No	ClinGen gnomAD
CA1584592 rs775137219	292	E>D		No	ClinGen ExAC gnomAD
CA346380698 rs1213918540	293	A>G		No	ClinGen TOPMed gnomAD
TCGA novel	294	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1220643122 CA346380675	295	L>P		No	ClinGen gnomAD
rs201935160 CA1584591	296	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770868932 CA1584588	299	D>G		No	ClinGen ExAC gnomAD
rs1281215989 CA346380620	300	Q>E		No	ClinGen gnomAD
CA44531184 rs1019378343	305	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs990588621 CA44531179	306	V>A		No	ClinGen gnomAD
rs761835617 CA44531178	307	L>F		No	ClinGen TOPMed gnomAD
CA346380527 rs1326385658	307	L>R		No	ClinGen gnomAD
rs749825803 CA1584587	308	G>R		No	ClinGen ExAC gnomAD
rs749825803 CA346380520	308	G>W		No	ClinGen ExAC gnomAD
CA1584585 rs756593192	311	S>I		No	ClinGen ExAC TOPMed gnomAD
CA1584582 rs758082498	312	E>D		No	ClinGen ExAC
CA1584583 rs781343480	312	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1584581 rs749994177 COSM1019858	313	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA346380453 rs1371616017	313	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	315	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	315	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346380425 rs1443070167	315	P>Q		No	ClinGen TOPMed
rs1380053467 CA346380361	320	V>A		No	ClinGen gnomAD
CA346380345 rs1465587958	321	E>D		No	ClinGen gnomAD
rs1305676017 CA346380338	322	A>T		No	ClinGen TOPMed
CA1584580 rs764831422	322	A>V		No	ClinGen ExAC TOPMed gnomAD
CA1584579 rs761444760	328	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1280978680 CA346380170	328	S>I		No	ClinGen gnomAD
CA346380165 rs1212675802	329	A>T		No	ClinGen gnomAD
rs368674223 CA1584557	338	N>S		No	ClinGen ESP ExAC gnomAD
rs753469353 CA1584556	339	L>Q		No	ClinGen ExAC gnomAD
rs1398254332 CA346380021	340	A>P		No	ClinGen gnomAD
rs1398254332 CA346380022	340	A>T		No	ClinGen gnomAD
CA346379962 COSM721339 rs1558497593	344	M>I	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA346379965 rs763634190	344	M>R		No	ClinGen ExAC gnomAD
CA1584555 rs763634190	344	M>T		No	ClinGen ExAC gnomAD
rs1437185058 CA346379939	346	P>A		No	ClinGen gnomAD
rs759289929 CA1584551	351	E>D		No	ClinGen ExAC TOPMed gnomAD
CA1584552 rs767377078	351	E>G		No	ClinGen ExAC TOPMed gnomAD
CA1584553 rs752532224	351	E>K		No	ClinGen ExAC gnomAD
rs774176578 CA1584550	352	G>R		No	ClinGen ExAC TOPMed gnomAD
rs200753357 CA1584549	353	N>S		No	ClinGen ExAC TOPMed gnomAD
CA346379823 rs1257690904	355	S>A		No	ClinGen TOPMed gnomAD
CA346379820 rs1189970300	355	S>F		No	ClinGen gnomAD
rs1482265203 CA346379817	356	G>E		No	ClinGen TOPMed gnomAD
CA44530465 rs913021339	356	G>R		No	ClinGen TOPMed
CA44530462 rs753972326	358	G>D		No	ClinGen Ensembl
rs769815979 CA1584546	361	G>A		No	ClinGen ExAC gnomAD
rs1377660202 CA346379752	366	E>G		No	ClinGen gnomAD
rs769180282 CA1584543	366	E>K		No	ClinGen ExAC gnomAD
CA346379739 rs1203541625	368	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA346379727 rs1558497514	369	M>I		No	ClinGen Ensembl
rs1261265298 CA346379733	369	M>V		No	ClinGen TOPMed
CA346379722 rs1443396924	370	S>*		No	ClinGen gnomAD
CA1584542 rs747388281	370	S>A		No	ClinGen ExAC gnomAD
CA346379721 rs1443396924	370	S>L		No	ClinGen gnomAD
CA1584541 rs780558973	371	G>D		No	ClinGen ExAC gnomAD
rs1009785534 CA44530452	372	M>V		No	ClinGen TOPMed gnomAD
rs537179168 CA1584539	375	A>G		No	ClinGen 1000Genomes ExAC gnomAD
rs200862829 CA1584540	375	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA346379691 rs200862829	375	A>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	377	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752221996 CA1584537	382	D>H		No	ClinGen ExAC gnomAD
CA1584536 rs752221996	382	D>N		No	ClinGen ExAC gnomAD
CA1584535 rs767404099	385	D>A		No	ClinGen ExAC TOPMed gnomAD
rs1421947022 CA346379626	385	D>N		No	ClinGen gnomAD
rs754931262 CA44530447	389	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1584534 rs754931262	389	G>D		No	ClinGen ExAC TOPMed gnomAD
CA346379582 rs1236199789	391	H>P		No	ClinGen gnomAD
CA346379558 rs1317557898	394	D>E		No	ClinGen gnomAD
rs766103531 CA1584532	395	S>T		No	ClinGen ExAC TOPMed gnomAD
rs763182708 CA1584531	398	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1584527 rs761844356	402	V>A		No	ClinGen ExAC TOPMed gnomAD
CA1584526 rs551999323	406	R>C		No	ClinGen ExAC TOPMed gnomAD
CA346379481 rs1445547251	406	R>H		No	ClinGen TOPMed gnomAD
rs1394806008 CA346379478	407	C>S		No	ClinGen gnomAD
CA44530423 rs1049202573	407	C>Y		No	ClinGen gnomAD
rs1415255201 CA346378759	411	M>I		No	ClinGen TOPMed
CA44530417 rs955537084	415	I>Q		No	ClinGen TOPMed

No associated diseases with O94864

1 regional properties for O94864

Type	Name	Position	InterPro Accession
domain	Bromodomain associated domain	151 - 230	IPR006565

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
SAGA complex	A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).

2 GO annotations of molecular function

Name	Definition
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

7 GO annotations of biological process

Name	Definition
histone H3 acetylation	The modification of histone H3 by the addition of an acetyl group.
maintenance of protein location in nucleus	Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
monoubiquitinated histone deubiquitination	The removal of the ubiquitin group from a monoubiquitinated histone protein.
monoubiquitinated histone H2A deubiquitination	The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of DNA repair	Any process that modulates the frequency, rate or extent of DNA repair.
regulation of RNA splicing	Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MNLQRYWGEI	PISSSQTNRS	SFDLLPREFR	LVEVHDPPLH	QPSANKPKPP	TMLDIPSEPC
70	80	90	100	110	120
SLTIHTIQLI	QHNRRLRNLI	ATAQAQNQQQ	TEGVKTEESE	PLPSCPGSPP	LPDDLLPLDC
130	140	150	160	170	180
KNPNAPFQIR	HSDPESDFYR	GKGEPVTELS	WHSCRQLLYQ	AVATILAHAG	FDCANESVLE
190	200	210	220	230	240
TLTDVAHEYC	LKFTKLLRFA	VDREARLGQT	PFPDVMEQVF	HEVGIGSVLS	LQKFWQHRIK
250	260	270	280	290	300
DYHSYMLQIS	KQLSEEYERI	VNPEKATEDA	KPVKIKEEPV	SDITFPVSEE	LEADLASGDQ
310	320	330	340	350	360
SLPMGVLGAQ	SERFPSNLEV	EASPQASSAE	VNASPLWNLA	HVKMEPQESE	EGNVSGHGVL
370	380	390	400	410
GSDVFEEPMS	GMSEAGIPQS	PDDSDSSYGS	HSTDSLMGSS	PVFNQRCKKR	MRKI