O94737
Gene name |
MKP1 |
Protein name |
Mitogen-activated protein kinase 1 |
Names |
MAP kinase Mkp1 |
Species |
Pneumocystis carinii |
KEGG Pathway |
|
EC number |
2.7.11.24: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
166-193 (Activation loop from InterPro)
Target domain |
21-314 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for O94737
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94737-F1 | Predicted | AlphaFoldDB |
No variants for O94737
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94737 | |||||
No associated diseases with O94737
4 regional properties for O94737
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 21 - 314 | IPR000719 |
| conserved_site | Mitogen-activated protein (MAP) kinase, conserved site | 58 - 161 | IPR003527 |
| active_site | Serine/threonine-protein kinase, active site | 145 - 157 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 27 - 53 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.24 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent protein binding | Binding to a protein or protein complex using energy from ATP hydrolysis. |
| MAP kinase activity | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular component organization | A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. |
| positive regulation of growth rate | Any process that increases the rate of growth of all or part of an organism. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSKHSVFNV | MGQEFVLQKG | YEVIKGLGKG | SYGVVCSAKN | IEVEDNNKVA | IKKITNIFSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KMLAKRALRE | IMLLQHFRNH | KNITTLYDMD | IVDPSKFNEL | YLYEELMQAN | LNSIIRSDQP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTDAHFQSFI | YQILCGLKYI | HSANVLHRDL | KPSNLLINAD | CKLKICDFGL | SRGISVNQGQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTEYMTEYVT | TRWYRAPEVM | LSFQSYSKAI | DLWSVGCILA | ELLGRKPFFK | GSNYVDQLNQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IFCILGTPNE | NIISKIKSAS | AQSYIRSLPT | LPKMPYSKIF | PYANPDALDL | LNCLLTFDPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DRISCEEALE | HPYLIIWHDP | NKEPVCSEQF | DFGFEAIDSI | EEIRQMIINE | VSRFKGLTGN |
| QKLYHSISNT |