O94672
Gene name |
sec232 (sec23b, SPBC776.04) |
Protein name |
Protein transport protein sec23-2 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC776.04 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94672
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94672-F1 | Predicted | AlphaFoldDB |
No variants for O94672
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94672 | |||||
No associated diseases with O94672
6 regional properties for O94672
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, Sec23/Sec24-type | 53 - 92 | IPR006895 |
| domain | Sec23/Sec24, trunk domain | 121 - 390 | IPR006896 |
| domain | Sec23/Sec24, helical domain | 517 - 615 | IPR006900 |
| domain | Gelsolin-like domain | 631 - 718 | IPR007123 |
| domain | Sec23/Sec24 beta-sandwich | 401 - 504 | IPR012990 |
| domain | Sec23, C-terminal | 610 - 730 | IPR037550 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPII vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum exit site | An endoplasmic reticulum part at which COPII-coated vesicles are produced. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| COPII-coated vesicle cargo loading | The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNFEDIEDQD | GIRLSWNTFS | ATPAENARAV | IPIAAMYTPL | HENERMTIEQ | YDPVACRAPC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAVLNPYCHV | DLRARFWICP | FCFQRNPLPA | QYSDISSNSL | PLELLSQSTT | MEYVLSKPVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPPVFLFVMD | TAVDESELTA | LKDAVIVSLS | LLPPDAIVGL | ITYGSLIQVH | EIGFEAMPKS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVFQPAADYS | TMKLQQLLAL | SGNQIRSSSS | KAKISGTGIT | LNLGAASRFL | MPVQKCEMHL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNILEQLQPD | CLEVPAGQRQ | LRCTGAAVKI | ASDLLGIAFP | KCGSRIELFC | GGPCTVGLGQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVSTELKEPM | RSHSEIANDK | AKHFKKSKKF | YSSLAERLSN | QGHALDLFAG | CLDQVGIMEM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ENLVNNTGGA | IVLSDSFTTS | IFKQSFQRLF | SVDASGYLKM | GFMANLEVLT | SKGLTICGMI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GNGVGENKKG | TNISDTQIGI | SKTNSWKMAA | ISPKSSYALY | FDLGKEMGNP | NSQRPTQAFI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QFLTYYQHSS | GTYRLRVTTI | SRSFITGNAK | SISESFDQEA | AAAIVARMAL | FKCQTEDEMS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VTRWIDRNLI | RLCQHFADYR | KEDPSSFRLL | PNFTLYPQFI | FHLRRSPFLH | IFNNSPDETS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FYRHMLNVAD | VNDSLIMIQP | TLQSYSFNEP | EGVPVLLDSV | SIKPDVILLL | DTYFHILIFH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GSTIAQWRNA | GYQEQPEYVN | LKELLLAPRL | EVTELLADRF | PIPRFIVCDQ | GGSQARFLLS |
| 730 | 740 | 750 | 760 | ||
| RINPSVSFNK | SSQFSPMSKD | SETVLTDDVN | LQKFMDHLRK | MAVIS |