O94641

PR
Gene name
hsp104 (SPBC16D10.08c)
Protein name
Heat shock protein 104
Names
Protein aggregation-remodeling factor hsp104
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC16D10.08c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-187 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94641

Entry ID Method Resolution Chain Position Source
AF-O94641-F1 Predicted AlphaFoldDB

No variants for O94641

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94641

No associated diseases with O94641

9 regional properties for O94641

Type Name Position InterPro Accession
domain AAA+ ATPase domain 201 - 348 IPR003593-1
domain AAA+ ATPase domain 613 - 787 IPR003593-2
domain ATPase, AAA-type, core 206 - 339 IPR003959-1
domain ATPase, AAA-type, core 613 - 778 IPR003959-2
domain Clp, repeat (R) domain 2 - 149 IPR004176
conserved_site ClpA/B, conserved site 1 298 - 310 IPR018368
domain Clp ATPase, C-terminal 785 - 876 IPR019489
conserved_site ClpA/B, conserved site 2 647 - 665 IPR028299
domain ClpA/ClpB, AAA lid domain 346 - 447 IPR041546

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleolar ring Ring-like structures located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein aggregate center Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein disaggregase activity An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
misfolded protein binding Binding to a misfolded protein.
unfolded protein binding Binding to an unfolded protein.

6 GO annotations of biological process

Name Definition
cellular heat acclimation Any process that increases heat tolerance of a cell in response to high temperatures.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
cellular response to misfolded protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.
chaperone cofactor-dependent protein refolding The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
protein unfolding The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADYPFTDKA AKTLSDAYSI AQSYGHSQLT PIHIAAALLS DSDSNGTTLL RTIVDKAGGD
70 80 90 100 110 120
GQKFERSVTS RLVRLPAQDP PPEQVTLSPE SAKLLRNAHE LQKTQKDSYI AQDHFIAVFT
130 140 150 160 170 180
KDDTLKSLLA EAGVTPKAFE FAVNNVRGNK RIDSKNAEEG FDALNKFTVD LTELARNGQL
190 200 210 220 230 240
DPVIGREDEI RRTIRVLSRR TKNNPVLIGE PGVGKTSIAE GLARRIIDDD VPANLSNCKL
250 260 270 280 290 300
LSLDVGSLVA GSKFRGEFEE RIKSVLKEVE ESETPIILFV DEMHLLMGAG SGGEGGMDAA
310 320 330 340 350 360
NLLKPMLARG KLHCIGATTL AEYKKYIEKD AAFERRFQII LVKEPSIEDT ISILRGLKEK
370 380 390 400 410 420
YEVHHGVTIS DRALVTAAHL ASRYLTSRRL PDSAIDLVDE AAAAVRVTRE SQPEVLDNLE
430 440 450 460 470 480
RKLRQLRVEI RALEREKDEA SKERLKAARK EAEQVEEETR PIREKYELEK SRGSELQDAK
490 500 510 520 530 540
RRLDELKAKA EDAERRNDFT LAADLKYYGI PDLQKRIEYL EQQKRKADAE AIANAQPGSE
550 560 570 580 590 600
PLLIDVVGPD QINEIVARWT GIPVTRLKTT EKERLLNMEK VLSKQVIGQN EAVTAVANAI
610 620 630 640 650 660
RLSRAGLSDP NQPIASFLFC GPSGTGKTLL TKALASFMFD DENAMIRIDM SEYMEKHSVS
670 680 690 700 710 720
RLIGAPPGYV GHEAGGQLTE QLRRRPYSVI LFDEIEKAAP EVLTVLLQVL DDGRITSGQG
730 740 750 760 770 780
QVVDAKNAVI IMTSNLGAEY LTTDNESDDG KIDSTTREMV MNSIRGFFRP EFLNRISSIV
790 800 810 820 830 840
IFNRLRRVDI RNIVENRILE VQKRLQSNHR SIKIEVSDEA KDLLGSAGYS PAYGARPLNR
850 860 870 880 890 900
VIQNQVLNPM AVLILNGQLR DKETAHVVVQ NGKIFVKPNH EANANGSADI DMDGIDDDVN
DEELE