O94624

PR
Gene name
tim54 (SPBC1347.04)
Protein name
Mitochondrial import inner membrane translocase subunit tim54
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1347.04
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

79-256 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94624

Entry ID Method Resolution Chain Position Source
AF-O94624-F1 Predicted AlphaFoldDB

No variants for O94624

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94624

No associated diseases with O94624

No regional properties for O94624

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O94624

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
TIM22 mitochondrial import inner membrane insertion complex A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein insertion into mitochondrial inner membrane The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKTIKSYMP GRNMSIFLGF VAGISGAIYY DRRQKNLIIE KYCSQVRHLA DQPMAPLELP
70 80 90 100 110 120
RKLKVYLHGP PGDGIYVARE EFEEYIRPIF NAAAIEFETV ESKGEGNLLE QVARTVYNKR
130 140 150 160 170 180
HNISEVSEPE KNLLSVLKPS VDPPAIVLLG RHALKEFLYG VRYGFSDDIM KRKLETEKLE
190 200 210 220 230 240
ANNKEEKEEK EGKDDKDDKE DSNDTKNDKK ISKNEVDSSL IEASPLTGQV PPKFLDTIAI
250 260 270 280 290 300
FPLPNLLGFS NTPKRLSRFF KRRELADELG AIAVNVALSR DVTKFPKQDG TLLLAEEETD
310 320 330 340
WPKQFFTRSD LENRIWTAPF LQDSDEIRFF ENIDIFDSTK AKQDKYE