O94587

PR
Gene name
cox18 (oxa1-3, oxa103, SPCC1442.15c)
Protein name
Cytochrome c oxidase assembly protein cox18, mitochondrial
Names
Sp3, cox18sp+
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1442.15c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

18-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94587

Entry ID Method Resolution Chain Position Source
AF-O94587-F1 Predicted AlphaFoldDB

No variants for O94587

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94587

No associated diseases with O94587

1 regional properties for O94587

Type Name Position InterPro Accession
domain Membrane insertase YidC/Oxa/ALB, C-terminal 20 - 199 IPR028055

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
membrane insertase activity Binds transmembrane domain-containing proteins and mediates their integration into a membrane.

5 GO annotations of biological process

Name Definition
mitochondrial cytochrome c oxidase assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane.
protein insertion into membrane The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
protein insertion into mitochondrial inner membrane from matrix The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.
protein insertion into mitochondrial membrane The process that results in the incorporation of a protein into a mitochondrial membrane.
respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLQTLIGVHS YMPWCYEIPA MAIFLRSTIT LPIAIASLKT ARRFVQVQPL IKEAKKRCRT
70 80 90 100 110 120
NTDFRTVRKK LYKRFNCHPL MIYALPITQL PLFAFASYQL RQAVDVCPES MSTEGMLWFT
130 140 150 160 170 180
DLTLPDPHGV LPAVLAVTYL TNMSILKRPS DSRLLKIFNT AGIMSAFFVS FMAFKTSTAL
190 200
SLYWTTSAIY SLVQNVALRK LL