O94545

PR
Gene name
kap113 (SPCC1322.06)
Protein name
Importin beta-like protein kap113
Names
Karyopherin-113
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1322.06
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94545

Entry ID Method Resolution Chain Position Source
AF-O94545-F1 Predicted AlphaFoldDB

No variants for O94545

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94545

No associated diseases with O94545

2 regional properties for O94545

Type Name Position InterPro Accession
domain Importin-beta, N-terminal domain 24 - 96 IPR001494
domain Exportin-1/Importin-beta-like 101 - 203 IPR013598

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nuclear rim
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
small GTPase binding Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name Definition
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQVDPVVYQL QRAVSQDPIA VKDAEGHLNN WKKEPGFFGK LYSIFLDKQN DMSLRWIAII
70 80 90 100 110 120
QLRNSIDIIW RKNTKMSLLP EERDFIRCNA LLGSIKSENL LSIQNALVVS RIARLDYPTE
130 140 150 160 170 180
WPSLFHDLLG KLQQSLGTGD YDVALRLLIT LHHIIKAMAG NRLLRSRQIF YKLAPELLTI
190 200 210 220 230 240
LQPILHSSLS SWMMILESSK EIKDSTLLSY MQISRYTLKA CRRLVVFGFQ NPSESEFSER
250 260 270 280 290 300
MLAFCAVHQR KLLSMLGTML QSSRSPIVVG ECLEMAFAHA FLFNKPFFDF SFYSPCLTKF
310 320 330 340 350 360
PATIDYISLH YDFLGQISSH LSSYKEKFEE SSKNFEKLVI MSLRVFILVI QEFCNTKSSH
370 380 390 400 410 420
PETAQVLYNS FLVDNRINNL LDLLITKLLI LKEEDFEEWT DSPQQWVLEQ STQDVEFNVR
430 440 450 460 470 480
PCAEKLLKCF FDAYGDIIVS PFKDMIYSVF ECPKTLTQAV QQDTLISSFG VGYTQLKSIF
490 500 510 520 530 540
PFAKWLQEAA VPNMASINDI GISRVYRRRI AIFLSQWIED SSSEQLLEVI YKLYCSFLNL
550 560 570 580 590 600
TDPCNDAVVI LTTIDAFKTV LDDWNFSENS FLSIKENLFV HVLSLFKAFE SVDARTSILS
610 620 630 640 650 660
LLGTLLARAG EHVAPMESTI ASLLSQLWDG WKKEPLLRAR VLAVMHQFVN AIKAKSFEFS
670 680 690 700 710 720
TFLYTVIEYC VNPESPEHVI FEADAMELWS TFLMYIQKLP ETFTLLIPHL LYHLSQATST
730 740 750 760 770 780
LPFVLMIVSS YQLLDNTVLM KDYSFTIFEK LNDLLDDVKN ETLQALCKTV CLLIETTPMD
790 800 810 820 830 840
MIYESLLNSS LLSRLLLSIA TNDKHPQVLI EYLLVVSRIS LREPELILKV CQTKNINIAM
850 860 870 880 890 900
LIGNWILLND HINHSKDRKL NTLALSSLLR TNHPDVLAVL DSIMNLWFSV LSEVEEDANG
910 920 930 940 950 960
DATIYYKNDD YSAVGFYLDE TSEEMTRRKQ LLLKDPVHSV NSRSFFISVF MFCRDANGGM
970 980
ENFQNQYLST VNPALLEQFQ SML