O94520

PR
Gene name
SPCC1281.03c
Protein name
ER membrane protein complex subunit 4
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1281.03c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-83 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94520

Entry ID Method Resolution Chain Position Source
AF-O94520-F1 Predicted AlphaFoldDB

No variants for O94520

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94520

No associated diseases with O94520

No regional properties for O94520

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O94520

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHINEETDWI DLVKPALAKK PKKIVDNSDK FPTPRGFQQK SLVSKNIHSG NSASSTSIFA
70 80 90 100 110 120
KREEELQKDL LLKKAWELAY SPLKQIPMNA ILAYMSGNSL QIFSIMTTLM LLVNPLKAIT
130 140 150 160 170 180
STGSAFTPFK GTHPGTLWPA MGAYILFQLL LMGIGVYKLQ RMGLLPTTTS DWLAWEVSKV
190
FMDRSYGPSK TVL