O94489

PR
Gene name
tef3 (ef3, SPCC417.08)
Protein name
Elongation factor 3
Names
EF-3
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC417.08
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

365-459 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94489

Entry ID Method Resolution Chain Position Source
AF-O94489-F1 Predicted AlphaFoldDB

No variants for O94489

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94489

No associated diseases with O94489

8 regional properties for O94489

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 411 - 647 IPR003439-1
domain ABC transporter-like, ATP-binding domain 673 - 1000 IPR003439-2
domain AAA+ ATPase domain 459 - 623 IPR003593-1
domain AAA+ ATPase domain 699 - 977 IPR003593-2
domain Elongation Factor 3, ABC2 domain, chromodomain-like insertion 802 - 868 IPR015688
conserved_site ABC transporter-like, conserved site 904 - 918 IPR017871
domain TOG domain 2 - 231 IPR034085
domain Elongation factor 3, four helical bundle domain 343 - 414 IPR040533

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.

2 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
cytoplasmic translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAKSENKQS VKALEELLKH LTVCDAAEEA DAAKALASFV NGPIEEQDAP SQVFSAISKQ
70 80 90 100 110 120
LNDKNATARE RVLKGLEAVA NHGSVAADVE PYLVELLPAV IAKVADKQNA VRDAAIAASK
130 140 150 160 170 180
AIVRCTTPYA VKAIVPSVLE SIHTTGKWNE KMNSLQLLDV LVEVAPSQLS YSLPQIIPVV
190 200 210 220 230 240
SESMWDTKAE VKKQSKETMT KVCTLIANAD IDRFIPELIN CIAHPEEVPE TIHSLGATTF
250 260 270 280 290 300
VTEVQAPTLS IMVPLLARGL NERSTPIKRK TAVIIDNMSK LVEDPQVVAP FLPKLLPGLY
310 320 330 340 350 360
HIKDTIGDPE CRSVVQRAIT TLERVGNVVD GKIPEVSTAA NPEVCLETLK AVLGEIKVPT
370 380 390 400 410 420
NEEVIAKYVA NIAAQLVEEK DNENESWVLN ITPYLTAFID EAHIHKIVEQ LRTRSIAKIP
430 440 450 460 470 480
GGASHAEEEE EGEDLCNCEF SLAYGAKILL NRTRLRLKRG RRYGLCGPNG SGKSTLMRAI
490 500 510 520 530 540
VNGQVEGFPT HLRTVYVEHD IDESEADTPS VDFILQDPAV PIKDRDEIVK ALKENSFTDE
550 560 570 580 590 600
LINMPIGSLS GGWKMKLALT RAMFKNPDIL LLDEPTNHLD VVNVAWLENF LVNQKDVSSI
610 620 630 640 650 660
IVSHDSGFLD HVVQAIIHYE RFKLRKYLGN MSEFVKKVPS AKSYYELGAS EMEFKFPEPG
670 680 690 700 710 720
FLEGVKTKQR AIIKVQHMSF QYPGTSKPQL NDISFQVSLS SRIAVIGPNG AGKSTLIKVL
730 740 750 760 770 780
TGELLPTVGE IYQHENCRIA YVAQAAFTHL GHHPDKTPSE YIQWRFQSGE DLEAMDKASR
790 800 810 820 830 840
VISEADEEAM KNKIFKIEGT QRKILGIHSR RKLKNSYEYE CSFLVGENIG MKSERWVPMM
850 860 870 880 890 900
SSDNAWLPRG ELMETHAKMV AEVDRAEALK SGQFRPLVRK EIEEHCSLLG LDAELVSHSR
910 920 930 940 950 960
IKGLSGGQKV KLVLAACTWL RPHVIVLDEP TNYLDRDSLG ALSKGLKNFG GGVVLVTHSR
970 980 990 1000 1010 1020
EFTEGLTEEV WAVNNGHMTP SGHNWVSGQG SGPRIQEKEE GDTFDAFGNK IEKAKKAKKL
1030 1040
TGAELRKKKK ERMARRKAGL EVSDDEL