O94457

PR
Gene name
erg31
Protein name
Delta(7)-sterol 5(6)-desaturase erg31
Names
C-5 sterol desaturase erg31, Ergosterol Delta(5,6) desaturase erg31, Ergosterol biosynthetic protein 31, Sterol-C5-desaturase erg31
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1687.16c
EC number
1.14.19.20: With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

229-299 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94457

Entry ID Method Resolution Chain Position Source
AF-O94457-F1 Predicted AlphaFoldDB

2 variants for O94457

Variant ID(s) Position Change Description Diseaes Association Provenance
I_933727_C_T 76 M>I No Jeffares_SNPs
I_933528_G_A 143 R>C No Jeffares_SNPs

No associated diseases with O94457

1 regional properties for O94457

Type Name Position InterPro Accession
domain Fatty acid hydroxylase 123 - 248 IPR006694

Functions

Description
EC Number 1.14.19.20 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
C-5 sterol desaturase activity Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.
delta7-sterol 5(6)-desaturase activity Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O.
iron ion binding Binding to an iron (Fe) ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDYLLNYADQ YALDSIYNAV YPLARDNIVR QSISLFFLTW FGGMFLYLTF ASLSYQFVFD
70 80 90 100 110 120
KSLMDHPKFL KNQVFMEVLT ALQNLPGMAL LTVPWFLAEL HGYSYLYDNI SDYGLKYFLC
130 140 150 160 170 180
SLPLFVMFSD FGIYWAHRFL HHRYVYPRLH KLHHKWIICT PYASHAFKSA DGFLQSLPYH
190 200 210 220 230 240
LFPFFFPLHK LTYLALFTFV NFWSIMIHDG KYISNNPIIN GAAHHNGHHI YFNYNYGQFT
250 260 270 280 290
TLFDRLGNSF RAPDEAWFDK DLRQNEDVLR VELMEYEAIR NEVEGDDDRE YIANSAKKNH