O94444

PR
Gene name
rpn10 (pus1, SPAC637.10c)
Protein name
26S proteasome regulatory subunit rpn10
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC637.10c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

192-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O94444

Entry ID Method Resolution Chain Position Source
2X5N X-ray 130 A A 2-193 PDB
AF-O94444-F1 Predicted AlphaFoldDB

1 variants for O94444

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4557878_A_G 192 V>A No Jeffares_SNPs

No associated diseases with O94444

2 regional properties for O94444

Type Name Position InterPro Accession
domain von Willebrand factor, type A 2 - 186 IPR002035
conserved_site Ubiquitin interacting motif 205 - 224 IPR003903

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.
proteasome regulatory particle, lid subcomplex The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.

3 GO annotations of molecular function

Name Definition
K48-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.
polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination of the target protein.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

4 GO annotations of biological process

Name Definition
mitotic recombination-dependent replication fork processing Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart.
mitotic sister chromatid separation The process in which sister chromatids are physically detached from each other during mitosis.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
stalled replication fork localization to nuclear periphery A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLEATMILI DNSEWMINGD YIPTRFEAQK DTVHMIFNQK INDNPENMCG LMTIGDNSPQ
70 80 90 100 110 120
VLSTLTRDYG KFLSAMHDLP VRGNAKFGDG IQIAQLALKH RENKIQRQRI VAFVGSPIVE
130 140 150 160 170 180
DEKNLIRLAK RMKKNNVAID IIHIGELQNE SALQHFIDAA NSSDSCHLVS IPPSPQLLSD
190 200 210 220 230 240
LVNQSPIGQG VVASQNQFEY GVDPNLDVEL ALALELSMAE ERARQEVAAQ KSSEETEDKK
MQE