O94416

PR
Gene name
tfg1 (SPCC1620.09c)
Protein name
Transcription initiation factor IIF subunit alpha
Names
TFIIF-alpha, TFIIF large subunit
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1620.09c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

319-482 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94416

Entry ID Method Resolution Chain Position Source
AF-O94416-F1 Predicted AlphaFoldDB

No variants for O94416

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94416

No associated diseases with O94416

No regional properties for O94416

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O94416

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
RNA polymerase II general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.
TFIIF-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II.

2 GO annotations of biological process

Name Definition
positive regulation of transcription elongation by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDSQETKVFE NVKQENPDEK KPKVEEPDSQ NNASTQSQQK FLDFQLSWCP ESERKTTKYH
70 80 90 100 110 120
LLKFHSNKAI DPSKSFVPPI KMQRRDPNAP SSSNGEQNAE QGSSSNVNIA SIAPYGGAQN
130 140 150 160 170 180
MKQNAFKRKT RQVVKVDPQA RRLQEEELSP WIMEDFEGKN TWVSTMEGGQ SSAYVLFMFS
190 200 210 220 230 240
ENGFKVIPTD RFYRFNQRNN FQTLSIDEAE AKMNKKTPIP RWFMKKESEE NLAEAGSASP
250 260 270 280 290 300
MYKLKTVPNA RPVTGPRASG SDDELDYDEE FADDEEAPIM EGNEEDNKKL KDKIKKEMLT
310 320 330 340 350 360
ANLFGEADQD VDLEEENDRQ MSREGKKLQR YLKLLEKNLA YESDEEDEDP YASSHDASSE
370 380 390 400 410 420
EEVLQEEEEL QKREEKLKSR FSANASKTNT PRPLERTPSS VSPVKASSQL QSPNTSIQIR
430 440 450 460 470 480
PQEQLINKPG YIILRLSSEK LSRFANDFPR MVPSMGSTET SVGDQVEVVG DTTNVPIDDS
490 500 510 520 530
NLITEAEVMK ALRAGPISIK DLVHLFQRKI RADNRNRLGI QKIIRKVARF ENKLLVLKNY