O94411
Gene name |
mfr2 (mug55, SPCC1620.04c) |
Protein name |
Meiotic fizzy-related protein 2 |
Names |
Meiotically up-regulated gene 55 protein |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC1620.04c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94411
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94411-F1 | Predicted | AlphaFoldDB |
No variants for O94411
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94411 | |||||
No associated diseases with O94411
5 regional properties for O94411
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 190 - 229 | IPR001680-1 |
| repeat | WD40 repeat | 234 - 272 | IPR001680-2 |
| repeat | WD40 repeat | 277 - 362 | IPR001680-3 |
| repeat | WD40 repeat | 430 - 467 | IPR001680-4 |
| domain | Anaphase-promoting complex subunit 4-like, WD40 domain | 196 - 253 | IPR024977 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| anaphase-promoting complex binding | Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. |
| ubiquitin ligase activator activity | Binds to and increases the activity of a ubiquitin ligase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| anaphase-promoting complex-dependent catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| positive regulation of anaphase-promoting complex-dependent catabolic process | Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIIKKKESFK | SPGRLWRVTK | IRKLTAAKKN | ELQNRKCNQA | SNEEKKILYK | SNFLDRFIPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KANSDAFRIM | ENAFTEKLNT | QESLLPDILN | LNVKGVLHYK | DNKKQKTTRL | IESTNYQRQT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IHGASSSLVI | EVEENGHLSN | MQGSLYETPL | RILDAPGLLD | DFYISPLAWS | TNGELAVALA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QNVYLWSEIS | GPSIMELSPT | TYEVSSLAYS | SDGGFLAIAR | VNGFVEIWNR | KTKNNRCDYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FHHDGDISCM | AWSPINWTLL | VGGSTGNIYV | YRRTKSMMRR | VHTIKKVHQE | QVCGLEWNYD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTQFASGGND | NLVCIFDIDS | LENKKFYWIH | LAAVKALAFC | PWQKSLLAVG | TGSNDQQIYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YDTFRGHRIH | SLFCGAQVTS | VIWSRRYKEF | CYSLGYSPEG | TNSSLIVYRW | PQLTKVFDIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SAAIDGWGQD | LRTIMAIHTH | RKYSNNTWEE | GEYVVVANSD | ETVKFYKIWG | NEMQEIHNDR |
| 490 | 500 | ||||
| VLYREGIFGS | HILEMLENIP | EQVLTNGVR |