O94397
Gene name |
sgf73 (SPCC126.04c) |
Protein name |
SAGA-associated factor 73 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC126.04c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94397
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94397-F1 | Predicted | AlphaFoldDB |
No variants for O94397
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94397 | |||||
No associated diseases with O94397
1 regional properties for O94397
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SCA7 domain | 183 - 256 | IPR013243 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SAGA complex | A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| heterochromatin assembly by small RNA | A heterochromatin formation-based gene silencing process mediated by a small RNA molecule that occur before the beginnning of trancription. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| RITS complex assembly | The aggregation, arrangement and bonding together of a set of components to form a RITS complex. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTEQQTLEL | FPENWERNEQ | VLLKYPDGLP | KDVLADQRVD | NTESQVKDEI | TSNITNQTQI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLPADSFPQY | GSYPNNSELD | YVVCTKCDRP | FLSEYIEDHH | SSCNGIKPPK | PQFEPVANSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLNKDVNNGN | NAPIKNGVKS | TAKGSAGNHE | KNSVNGQKNP | EMPPKRRKTE | ENKKPTKSAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PKKEASKKKN | PKVKGPVDVE | KQCGVLLPNG | QMCARSLTCK | THSMSSKRAV | PGRSQPYDVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LAACQKKNQV | KIQRQILETA | KESEDNQHQA | PVDSDEEVSF | IMNVLQKSGN | QPLEQKVFLP |
| 310 | 320 | 330 | 340 | ||
| VKRRHSYFRT | RELIAAAFRH | GEQGMQVTGT | ILGRVIPFSA | RQPL |