O94396
Gene name |
pus1 (lps1, SPCC126.03) |
Protein name |
tRNA pseudouridine synthase 1 |
Names |
tRNA pseudouridylate synthase 1, tRNA-uridine isomerase 1 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC126.03 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94396
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94396-F1 | Predicted | AlphaFoldDB |
No variants for O94396
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94396 | |||||
No associated diseases with O94396
1 regional properties for O94396
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pseudouridine synthase I, TruA, alpha/beta domain | 330 - 429 | IPR020097 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| snRNA pseudouridine synthase activity | Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| mRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. |
| snRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. |
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRGGKRTWY | NGDRREAKRN | RPNSIYNGEG | RPENLVVGEK | KPKRKVACLV | GYCGSGYHGM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLNPPSKTIE | GDLFDAFVKA | GAVSSYNADD | PKKVALARAA | RTDKGVHAAG | NVISLKLIME |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DEKLIEKVNE | HLPPSIRLWD | VIRTINSFNP | RTYCESRIYE | YMVPTYAFVP | PKPSSILGNC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IMKNSPMPAE | PINKENINQL | SRSLFYEEGK | EFWDDYDIAA | KEILSLYEQD | PEGFVNPYSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RGAAALANSE | NNKGSEAGVS | AKTNPDMDSD | SSAIVNEFLK | PDSVEDESAG | SKIDPSYRLE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RALKHIEVLK | LKNYRISADR | LSVIRETLNQ | YVGVHNFHNF | TVGQAFHQKN | SNRVIRSFTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDPFMIGDTE | WISCKVHGQS | FMLHQIRKMI | ALAILVVRTG | CPVERIQDAF | KKTKINIPKG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PGFGLLLESP | FFKGYNEHKA | PENNRDPIDF | TKYEQKITAF | KHAHIYDKIF | LEEARKQVFH |
| 490 | 500 | 510 | 520 | 530 | |
| CFLSFIDSYN | EEDFSYLSDI | GITEKTQEVS | SKLPDVLSSD | EEEDSAENKD | DLEG |