O94374

PR
Gene name
imp1 (SPBC1604.08c)
Protein name
Importin subunit alpha-2
Names
Importin-1, Karyopherin subunit alpha-2
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1604.08c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94374

Entry ID Method Resolution Chain Position Source
AF-O94374-F1 Predicted AlphaFoldDB

No variants for O94374

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94374

No associated diseases with O94374

7 regional properties for O94374

Type Name Position InterPro Accession
repeat Armadillo 109 - 235 IPR000225-1
repeat Armadillo 238 - 277 IPR000225-2
repeat Armadillo 279 - 361 IPR000225-3
repeat Armadillo 363 - 403 IPR000225-4
repeat Armadillo 408 - 448 IPR000225-5
domain Importin-alpha, importin-beta-binding domain 1 - 99 IPR002652
repeat Atypical Arm repeat 462 - 511 IPR032413

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Nucleus; nucleolus; nuclear rim
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitotic spindle midzone The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

5 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
mitotic nuclear pore complex disassembly The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis.
NLS-bearing protein import into nucleus The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
regulation of mitotic nuclear envelope disassembly Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESRYLSDRR SRFKSKGVFK ADELRRQREE QQIEIRKQKR EESLNKRRNL NAVLQNDIDV
70 80 90 100 110 120
EEEADQSQVQ MEQQMKDEFP KLTADVMSDD IELQLGAVTK FRKYLSKETH PPIDQVIACG
130 140 150 160 170 180
VVDRFVQFLE SEHHLLQFEA AWALTNIASG TTDQTRIVVD SGAVPRFIQL LSSPEKDVRE
190 200 210 220 230 240
QVVWALGNIA GDSSACRDYV LGNGVLQPLL NILQSSASDV SMLRNATWTL SNLCRGKNPP
250 260 270 280 290 300
PNWSTISVAV PILAKLLYSE DVEIIVDACW AISYLSDGPN EKIGAILDVG CAPRLVELLS
310 320 330 340 350 360
SPSVNIQTPA LRSVGNIVTG TDAQTQIIID CGALNAFPSL LSHQKENIRK EACWTISNIT
370 380 390 400 410 420
AGNTQQIQAI IESNLIPPLV HLLSYADYKT KKEACWAISN ATSGGLGQPD QIRYLVSQGV
430 440 450 460 470 480
IKPLCDMLNG SDNKIIQVAL DAIENILKVG EMDRTMDLEN INQYAVYVEE AGGMDMIHDL
490 500 510 520 530
QSSGNNDIYL KAYSIIEKYF SDEDAVEDLA PETENGAFTF GNGPQAQGEF KFDSQDMAM