O94365
Gene name |
utp15 (SPBC428.19c) |
Protein name |
U3 small nucleolar RNA-associated protein 15 |
Names |
U3 snoRNA-associated protein 15, U3 protein 15 required for transcription |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC428.19c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94365
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94365-F1 | Predicted | AlphaFoldDB |
No variants for O94365
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94365 | |||||
No associated diseases with O94365
9 regional properties for O94365
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 70 - 109 | IPR001680-1 |
| repeat | WD40 repeat | 112 - 195 | IPR001680-2 |
| repeat | WD40 repeat | 197 - 234 | IPR001680-3 |
| repeat | WD40 repeat | 239 - 319 | IPR001680-4 |
| domain | U3 small nucleolar RNA-associated protein 15, C-terminal | 350 - 492 | IPR018983 |
| conserved_site | WD40 repeat, conserved site | 180 - 194 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 139 - 153 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 180 - 194 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 265 - 279 | IPR020472-3 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| t-UTP complex | A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| snoRNA binding | Binding to a small nucleolar RNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| positive regulation of transcription by RNA polymerase I | Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAPAGRLQP | QRFAALPNPV | TAENKFWRSF | KVPVVAKEYS | AITSIHFSAE | SPYDFAVTSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARVQIYGASS | RSVKKTIARF | KDTAYSGNIR | KDGKLLLAGD | ATGLVQIFDL | STRSILRALD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AHQFPVHVTQ | FCPYANTTFL | SGSDDKTVKV | WDLSTGAVQY | DLSGHEDYVR | TASWMSATRL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSGGYDGTIR | LWDTRIADPE | VMSFSHGEAI | DVVLPMQSGS | TVISAGGPSI | KVWDLVAGRQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPTKKLSNHQ | KSITCLAMNS | ENTRLLSGGL | DGHVKIYNIS | DWKVVHGMKY | SGPILSMGLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDSCNLVVGM | SNGTLSQRTR | RITKQTSSKT | PFLGGVGSAF | GVVGKKKQIY | KGENDEFYVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EARRKRLRPF | DKALKSFCYS | DALDMVLENG | SPVLIITMLI | ELLHVGGLRI | ALSNRDDLSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TPLINFLRKY | IRDPRFSETL | CIVTSTILDI | YGAALGGSVM | VENAISKLRE | KVEQEVAVTQ |
| 490 | |||||
| RANELVGMLQ | MLSA |