O94355

PR
Gene name
rtx2 (SPBC428.06c)
Protein name
Transcriptional regulatory protein rxt2
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC428.06c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O94355

Entry ID Method Resolution Chain Position Source
8I03 EM 320 A F 1-240 PDB
AF-O94355-F1 Predicted AlphaFoldDB

No variants for O94355

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94355

No associated diseases with O94355

1 regional properties for O94355

Type Name Position InterPro Accession
domain Transcriptional regulatory protein RXT2, N-terminal 33 - 156 IPR013904

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Clr6 histone deacetylase complex I'' A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Rpd3L complex A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
histone deacetylation The modification of histones by removal of acetyl groups.
negative regulation of ribosomal DNA heterochromatin assembly Any process that decreases the rate, frequency, or extent of rDNA heterochromatin formation.
negative regulation of silent mating-type cassette heterochromatin assembly Any process that decreases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
transfer RNA gene-mediated silencing The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQFEEQIER FKQALFEDSD ASDSDSSIGE ALTNRGLKRK KGSKNVYYGC VGNSSGSSID
70 80 90 100 110 120
IDYYNIGNTK RGVVSHFRRR IDPEWLDHDN PYNDINIAEI MSPLTKPQDL LTHPAISSIF
130 140 150 160 170 180
EQNYLSILAS SALEIISAEH KYTAHLEQLM VALLGDDPSL PGPPHEVFGI SPEQCRELTI
190 200 210 220 230
TVQEALEKSK EFIRCWTNVR MDLLRAIRFK NKVIAYCQGE DYNGNTQVLS KNESDGKPNS