O94280
Gene name |
SPBC2G5.01 |
Protein name |
UPF0674 endoplasmic reticulum membrane protein C2G5.01 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC2G5.01 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O94280
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O94280-F1 | Predicted | AlphaFoldDB |
No variants for O94280
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O94280 | |||||
No associated diseases with O94280
No regional properties for O94280
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O94280 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| PAT complex | A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| protein folding chaperone | Binding to a protein or a protein-containing complex to assist the protein folding process. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. |
| protein insertion into ER membrane | The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MINKKLLFLV | FALAKGVLAD | EEDEYEEDYN | MNPELENPGM | FKHVDWRDFR | LEFVILACFF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LYVFSFITQK | KKNQKIASRW | YGSLQSSFRQ | QFAQYGPGPN | SSPIIYDSPT | EFSSYLTGRL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NVKNVYTTLQ | LFPRQDLLAY | SLNQIVEILL | GNVMSSVLPV | ADRFQFDLTL | ADQNLKAERF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VFAIVHKDCM | RILREIRYDL | SFTRISSSPY | LPETHVLMSE | NNECSQAIFE | IPEFMSSINE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CIENLEYFIV | TDQPSVPPAT | EKDYVTKPRI | EASIRIKKIT | SLSGLSNATG | SALFNSLLLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADSCPKFQWR | PEVSKKLTSA | RKLAFEQVVH | ASAAKAAKKK | VKSSGDISKL | SESDQKKRME |
| 370 | |||||
| RERQRKMRRR | AKKM |