O94048

PR
Gene name
HEM3 (CAALFM_C210360CA, Ca38F10.02, CaO19.1742, CaO19.9309)
Protein name
Porphobilinogen deaminase
Names
PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C210360CA
EC number
2.5.1.61: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O94048

Entry ID Method Resolution Chain Position Source
AF-O94048-F1 Predicted AlphaFoldDB

No variants for O94048

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O94048

No associated diseases with O94048

3 regional properties for O94048

Type Name Position InterPro Accession
domain Porphobilinogen deaminase, N-terminal 14 - 229 IPR022417
domain Porphobilinogen deaminase, C-terminal 242 - 316 IPR022418
binding_site Porphobilinogen deaminase, dipyrromethane cofactor binding site 247 - 263 IPR022419

Functions

Description
EC Number 2.5.1.61 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
hydroxymethylbilane synthase activity Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).

3 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
peptidyl-pyrromethane cofactor linkage The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine.
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPHHIMSIND SNHVQIGGRK SKLAVVQSEI VKKVIEDTFP NLSCSILALS TLGDKVQTQP
70 80 90 100 110 120
LYTFGGKSLW TKELEILLLD SVDEFPKLDL IVHSLKDMPT NLPEEFELGC IFQREDPRDA
130 140 150 160 170 180
IVMKQGSSYK SLKDLPAGAI VGTSSIRRSS QLIKNYPHLR FESVRGNIQT RLNKLDQPNN
190 200 210 220 230 240
EYCCLILASA GLIRLGLGHR ITSYLDDMYY AVGQGALGIE IRKGDDNIKS ILKKIEDPIA
250 260 270 280 290 300
TICCLAERSL MRYLEGGCSV PLGVHSDYNE SKQELTLKGI IVSPDGTVSI EDEVIKRITC
310 320 330
DEDCEQVGIE LGDKLKAKGA KEILDKIDMT RNINARPTEV