O93927

PR
Gene name
FKS1 (CNAG_06508)
Protein name
1,3-beta-glucan synthase component FKS1
Names
Species
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
KEGG Pathway
EC number
2.4.1.34: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-169 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O93927

Entry ID Method Resolution Chain Position Source
AF-O93927-F1 Predicted AlphaFoldDB

No variants for O93927

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O93927

No associated diseases with O93927

5 regional properties for O93927

Type Name Position InterPro Accession
conserved_site Actinin-type actin-binding domain, conserved site 211 - 235 IPR001589
domain Calponin homology domain 122 - 239 IPR001715-1
domain Calponin homology domain 267 - 370 IPR001715-2
domain Calponin homology domain 392 - 498 IPR001715-3
domain Calponin homology domain 513 - 621 IPR001715-4

Functions

Description
EC Number 2.4.1.34 Hexosyltransferases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perinuclear endoplasmic reticulum The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).

3 GO annotations of biological process

Name Definition
(1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds.
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYPNPPPPP KGSASFSSSS SDPFNQTNQL PYDSQFPPQH AFAHPSAPNP GAGGAGVAPP
70 80 90 100 110 120
GQGGQYAPYY DNEPEMGGRW EGGGMGRETW ASESGWSQNE PNYPPSDYHG GPGYLPSRAS
130 140 150 160 170 180
TPTFEGSNAG HRPRDPYPAW TVDANIPLSK EEIEDVLIDL ANKFGFQKDS SRNVYDFLMI
190 200 210 220 230 240
QLDSRASRMS PNQALLTLHA DYIGGEHANY RKWYFAAQLD LDDAIGAVQN PGLNRVRSVA
250 260 270 280 290 300
RRGGKTKNPL ATAQEKSLES ATSRWRTAMN NMSQYDRLRQ VALYLLCWGE AAQVRFMPEC
310 320 330 340 350 360
LCFIFKCADD YYRSPECQNR QEAVPEGLYL RAVIKPLYRF LRDQGYEVVD GKFLRRERDH
370 380 390 400 410 420
DKVIGYDDVN QLFWYPEGIS RITLNDNTRL VDIPPAQRFM KFDRIDWNKV FFKTYLEKRS
430 440 450 460 470 480
FFHLLVNFNR IWVLHISVFW FFTAYNAPSI YAPSGSTTAT TPMAWSMTGL GGFVATLIMI
490 500 510 520 530 540
AATLAEFSYI PTTWNNTSHL TRRLIFLLII LAITGGPSIY IAFFNQTGHV ALILGIVQFF
550 560 570 580 590 600
CSVVATIAFA TLPSGRMFGD RVAGKSRKYL ANQTFTASYP ALGFYPRVAS FLLWFLVFGC
610 620 630 640 650 660
KFTESYFFLT LSFRDPMKVM NGMKVQNCHD KYFGNGLCTN QPAFALAVMF VMDLTLFFLD
670 680 690 700 710 720
TFLWYVIWNT VFSIARSFAI GMSIWTPWKD IFARLPKRIY AKILATDDME VKYKPKVLVS
730 740 750 760 770 780
QVWNAVIISM YREHLLSIEH VQKLLYHQIQ SDQPGKRTLR APAFFISQSE KGSKAEFFPK
790 800 810 820 830 840
GSEAERRICF FAQSLTTSIP APIPVDAMPT FTVLVPHYSE KILLSLREII REEDQNTRVT
850 860 870 880 890 900
LLEYLKQLHP VEWDNFVRDT KILAEESDAF NGGNPFASDE KEEAKKADDI PFYTIGFKSA
910 920 930 940 950 960
APEYTLRTRI WASLRAQTLY RTVSGFMNYS KAIKLLYRVE NPEVVQLFGG NTDQLERELE
970 980 990 1000 1010 1020
RMARRKFKFV VSMQRYSKFN KEEHENAEFL LRAYPDLQIA YLDEEPPRKD GGESRIFSAL
1030 1040 1050 1060 1070 1080
IDGHSEIMPN GRRRPKFRIE LPGNPILGDG KSDNQNHAIV FYRGEYLQLI DANQDNYLEE
1090 1100 1110 1120 1130 1140
CLKIRNVLGE FEEFKVSTQS PYAAQGHADF AKFPVAILGA REYIFSENIG ILGDIAAGKE
1150 1160 1170 1180 1190 1200
QTFGTLAARS LSYIGGKLHY GHPDFLNAIY MNTRGGVSKA QKGLHLNEDI FAGMLAFGRG
1210 1220 1230 1240 1250 1260
GRIKHSEYYQ CGKGRDLGFG TILNFQTKIG TGMGEQMLSR EYYYLGTQLP IDRFLTFYYG
1270 1280 1290 1300 1310 1320
HPGFHINNIL VMMSVQVFML ALVFLGTLNK QLTVCRYSSG GDILPGQSGC YNLVPVFKWI
1330 1340 1350 1360 1370 1380
KRCIISIFIV FWIAFVPLFV QELTERGTGR AILRLCKHFL SLSPVFEVFS TQIYMHSILN
1390 1400 1410 1420 1430 1440
DLTFGGARYI ATGRGFATTR ISFSILYSRF AGPSIYLGMR TLVLLLFITL TVWVPHLIYF
1450 1460 1470 1480 1490 1500
WITVVGLCVA PFLFNPHQFA IADFIIDYRE FLRWMSRGNS RTHANSWVGY CRLSRTRVTG
1510 1520 1530 1540 1550 1560
FKRKRLGLPS EKLSSDVPRA PWKAILIGEI IGPICLAILF VICYLFIKSF AVDGQIQPGL
1570 1580 1590 1600 1610 1620
VRIAIIALGP IVWNMALLIT LFLISVFLGP CLNSYTHQFG ATMAALAHFG AVAGMLVFFE
1630 1640 1650 1660 1670 1680
LLWFLELWNT SHAVLGIIAV ISVQRCIFKF LIAVFLSREF KHDETNRAWW TGVWFNRGLG
1690 1700 1710 1720 1730 1740
SHALSQPARE FVVKTIEMGL YSADFIACHL LLALLTIPMF IPYFDRVHAT MLFWLAPNQQ
1750 1760 1770 1780 1790
IRPPIYSFRQ RSQRRKIVFK YGLLYLIIQG IFIALIVVPI IFKDVAGLTP KSVPFNGII