O93746

PR
Gene name
polB (APE_2098.1)
Protein name
DNA polymerase 2
Names
DNA polymerase II
Species
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
KEGG Pathway
ape:APE_2098.1
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

127-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O93746

Entry ID Method Resolution Chain Position Source
AF-O93746-F1 Predicted AlphaFoldDB

No variants for O93746

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O93746

No associated diseases with O93746

3 regional properties for O93746

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 35 - 317 IPR006133
domain DNA-directed DNA polymerase, family B, multifunctional domain 384 - 777 IPR006134
conserved_site DNA-directed DNA polymerase, family B, conserved site 579 - 587 IPR017964

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKGSDATLLS FQLLDVSYEM RGSTPVIILW GRGADGSRVV VFYGEFRPYF YVLPDGSVGL
70 80 90 100 110 120
DQLAAMIRRL SRPSSPILSV ERVRRRFIGR EVEALKVTTL VPASVREYRE AVRRLGGVRD
130 140 150 160 170 180
VLEADIPFAL RFIIDFNLYP MRWYVAEVRE VAVPHGYSVD RAYTLSGDIR EDETRIQEDP
190 200 210 220 230 240
LKGLRVMAFD IEVYSKMRTP DPKKDPVIMI GLQQAGGEIE ILEAEDRSDK KVIAGFVERV
250 260 270 280 290 300
KSIDPDVIVG YNQNRFDWPY LVERARVLGV KLAVGRRSVE PQPGLYGHYS VSGRLNVDLL
310 320 330 340 350 360
DFAEELHEVK VKTLEEVADY LGVVKIGERV TLEWWQIGEY WDDPSKREIL RKYLRDDVRS
370 380 390 400 410 420
TMGLAEKFLP FGAELSQVSG LPLDQVMAAS VGFRLEWRLI REAAKLGELV PNRVERSEGR
430 440 450 460 470 480
YAGAIVLRPK PGVHEDIAVL DFASMYPNIM VKYNVGPDTL VRPGEEYGEE EVYTAPEVGH
490 500 510 520 530 540
KFRKSPPGFF KKILERFLSW RRQIRSEMKK HPPDSPEYKL LDERQKAIKL LANASYGYMG
550 560 570 580 590 600
WPHARWYCRE CAEAVTAWGR SIIRTAIRKA GELGLEVIYG DTDSLFVKND PEKVERLIRF
610 620 630 640 650 660
VEEELGFDIK VDKVYRRVFF TEAKKRYVGL TVDGKIDVVG FEAVRGDWSE LAKETQFKVA
670 680 690 700 710 720
EIVLKTGSVD EAVDYVRNII EKLRRGQVDM RKLVIWKTLT RPPSMYEARQ PHVTAALLME
730 740 750 760 770 780
RAGIKVEPGA KIGYVVTKGS GPLYTRAKPY FMASKEEVDV EYYVDKQVVP AALRILQYFG
790 800
VTEKRLKGGG RQSTLLDFMR RGK