O91087

PR
Gene name
nef
Protein name
Protein Nef
Names
3'ORF, Negative factor, F-protein
Species
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for O91087

Entry ID Method Resolution Chain Position Source

No variants for O91087

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O91087

No associated diseases with O91087

No regional properties for O91087

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O91087

Functions

Description
EC Number
Subcellular Localization
  • Host cell membrane ; Lipid-anchor ; Cytoplasmic side
  • Virion
  • Secreted
  • Host Golgi apparatus membrane
  • TGN localization requires PACS1
  • Associates with the inner plasma membrane through its N-terminal domain
  • Nef stimulates its own export via the release of exosomes
  • Incorporated in virions at a rate of about 10 molecules per virion, where it is cleaved
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
host cell Golgi membrane The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus.
host cell plasma membrane The plasma membrane surrounding a host cell.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

3 GO annotations of biological process

Name Definition
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response.
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex.
suppression by virus of host autophagy Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKIWSKSSL VGWPEIRERM RRQTQEPAVE PAVGAGAASQ DLANRGAITI RNTRDNNESI
70 80 90 100 110 120
AWLEAQEEEE EVGFPVRPQV PLRPITYKQA FDLSFFLKDK GGLEGLVWSR KRQDILDLWM
130 140 150 160 170 180
YHTQGILPDW HNYTPGPGIR YPVTFGWCFK LVPLSAEEVE EANEGDNNAL LHPICQHGAD
190 200 210
DDHKEVLVWR FDSSLARRHV ARELHPEFYK NC