O84799

PR
Gene name
dnaG
Protein name
DNA primase
Names
Species
Chlamydia trachomatis (strain D/UW-3/Cx)
KEGG Pathway
ctr:CT_794
EC number
2.7.7.101: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

67-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O84799

Entry ID Method Resolution Chain Position Source
AF-O84799-F1 Predicted AlphaFoldDB

No variants for O84799

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O84799

No associated diseases with O84799

5 regional properties for O84799

Type Name Position InterPro Accession
domain Zinc finger, CHC2-type 4 - 97 IPR002694
domain TOPRIM domain 251 - 331 IPR006171
domain DNA primase, DnaG 3 - 408 IPR006295
domain DNA primase, catalytic core, N-terminal 125 - 241 IPR013264
domain Bacterial DnaG primase, TOPRIM domain 251 - 330 IPR034151

Functions

Description
EC Number 2.7.7.101 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.
primosome complex Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA primase activity Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYYTEESLET LKHSIDIVSV LGEYVHLKRS GADYKACCPF HDEKTPSFIV YPTRGHYHCY
70 80 90 100 110 120
GCGEHGDAIN FLMKQQGYSF SEAVLFLAKK FHVDLVVRTK ETSGQDSKDS LRRINREAER
130 140 150 160 170 180
FFQYCLLHLP EGEEALAYLY KRGFSPDTID RFQIGYAPEQ RLFIQAMEER NISVKQLEWA
190 200 210 220 230 240
GYLAKDWFLF AQRIMFPIQD ALGYTIGFSS RRFKEGGRGG KYINSPETIL FKKSRVLYGL
250 260 270 280 290 300
QFSRKRIAKE RRVILVEGQA DCLQMIDFGF NCTLAAQGTS FTETHVHELV KLGVSKAYLL
310 320 330 340 350 360
FDGDAAGEKA SLRVGDLCQA AGITAIVCRL PSGQDPDSFL MQRGPEELRE LLDRGEDYLS
370 380 390 400 410 420
FLVWHKIHSY EQFTPREKAR VIEEVIQQVR CWGSPITIHE YLRQLASLVK VPEPAVLSYL
430 440 450 460 470 480
SSITSAAEDK GKKVSAKEPS SESKQTSTEG KISKKISPRM ILEADVIRCL LFAKPEDEFV
490 500 510 520 530 540
PATVKQYLSP EEFHCAEYRA IFVMAMNHYN DRQTLPSMDE MMSLVVGTEA MTLLVARRMN
550 560 570 580 590
TELMRDIVVQ SIQKLLDKHW RDKKRKLCHQ TGKGLDSLQE YVRLSGERVK VSLVS