O84439

PR
Gene name
glyA
Protein name
Serine hydroxymethyltransferase
Names
SHMT, Serine methylase
Species
Chlamydia trachomatis (strain D/UW-3/Cx)
KEGG Pathway
ctr:CT_432
EC number
2.1.2.1: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O84439

Entry ID Method Resolution Chain Position Source
AF-O84439-F1 Predicted AlphaFoldDB

No variants for O84439

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O84439

No associated diseases with O84439

3 regional properties for O84439

Type Name Position InterPro Accession
binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site 281 - 297 IPR019798
domain Serine hydroxymethyltransferase-like domain 39 - 136 IPR039429-1
domain Serine hydroxymethyltransferase-like domain 168 - 442 IPR039429-2

Functions

Description
EC Number 2.1.2.1 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
serine binding Binding to 2-amino-3-hydroxypropanoic acid.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.
L-serine catabolic process The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASLLDRYLR NISDKSQQNL ASVAYLASLD HLLHAFPSIG QSIVQELKSQ RSRLKMIASE
70 80 90 100 110 120
NFSSLSVQLA MGNLLTDKYC EGSPFKRFYS CCENVDAIEW ECAETAKELF GAESAFVQPH
130 140 150 160 170 180
SGADANLLAI MSIITQKIQS PAVQRLGYKT INDLPEQEYE ALKAEMAQHK CLGPSLNSGG
190 200 210 220 230 240
HLTHGTVRMN IMSKLMHCLP YEVNLDTELF DYDEIAKIAK EHKPTVLIAG YSSYSRRLNF
250 260 270 280 290 300
ATLKQIAEDC GAVLWVDMAH FAGLVAGGVF VGEENPMPYA DIVTTTTHKT LRGPRGGLVL
310 320 330 340 350 360
AKKEYANTLN KACPLMMGGP LPHVIAAKAI ALKEAMTINF RKYAHKVVEN ARTLAEVFQR
370 380 390 400 410 420
NGLRLLTGGT DNHMLIIDLT SLGVPGRIAE DMLTSVGIAV NRNTIPSDAS GQWKTSGIRL
430 440 450 460 470 480
GTPALTTLGM GSAEMEEVAN IIVKVLRNIT VRSNAESGSS KSEGELSEGI AQEARQRVAD
490
LLGRFPLYPE IDLETLV