O84211

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Chlamydia trachomatis (strain D/UW-3/Cx)
KEGG Pathway
ctr:CT_209
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O84211

Entry ID Method Resolution Chain Position Source
AF-O84211-F1 Predicted AlphaFoldDB

No variants for O84211

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O84211

No associated diseases with O84211

4 regional properties for O84211

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 672 - 785 IPR013155
domain Methionyl/Leucyl tRNA synthetase 38 - 171 IPR015413
domain Leucyl-tRNA synthetase, editing domain 219 - 361 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRYDPGLIEE KWQKFWENEQ VFKAEEDETK TKYYVLDMFP YPSGAGLHVG HLIGYTATDI
70 80 90 100 110 120
VARYKRAQGF SVLHPMGWDS FGLPAEQYAI RTGTHPRETT EKNIANFKKQ LTAMGFSYDE
130 140 150 160 170 180
SREFATSDPE YYKWTQKLFL ILYEKGLAYM ADMAVNYCPE LGTVLSNEEI ENGFSVDGGY
190 200 210 220 230 240
PVERRMLRQW VLRITAFADQ LLEGLDELDW PESVKQLQKN WIGKSSGASV NFATEHGVIE
250 260 270 280 290 300
VFTTRPDTLI GVSFLALAPE HPLVDLLTSD EQKAVVAQYI KETQSKSERD RISEMKTKSG
310 320 330 340 350 360
VFTGSYAKHP VTHKLIPIWI ADYVLIGFGS GAVMGVPAHD ERDLLFAEQF NLPVVSVLNK
370 380 390 400 410 420
EGVCINSCCE GFHLDGLSGE EAKQYVINFL EENHLGAAKI AYKLRDWLFS RQRYWGEPIP
430 440 450 460 470 480
IIHFEDGSCR PLRDYELPLL PPEIQDYRPE GVGQGPLAKV REWVQVFDTE TQRAGKRETH
490 500 510 520 530 540
TMPQWAGSCW YYLRFCDAHN SAAPWAKEKE QYWMPVDLYI GGAEHAVLHL LYARFWHQVF
550 560 570 580 590 600
YEAGIVSTPE PFKKLVNQGL VLATSYRIPG KGYIYPEIAK EENGKWVAPS GEELDVRQEK
610 620 630 640 650 660
MSKSKLNGVD PQILIDEFGA DAVRMYAMFS GPLDKNKLWS NQGVAGCRRF LNRFYEMVSS
670 680 690 700 710 720
DRVKEDNNFE GLSLAHKLVQ RVTDAIEKLS LNTIPSSFME FINDFVKLAV YPKSAVEMAV
730 740 750 760 770 780
RALAPIAPHI SEELWVLLGN SPGVQKSGWP SVLPEYLEGQ TVTIVVQVNG KLRARLDIMK
790 800 810
DASKEEVLAL ARESASKYLE GCEVKKAIFV PARLVNFVV