O83809

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Treponema pallidum (strain Nichols)
KEGG Pathway
tpa:TP_0837
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-343 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O83809

Entry ID Method Resolution Chain Position Source
AF-O83809-F1 Predicted AlphaFoldDB

No variants for O83809

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O83809

No associated diseases with O83809

6 regional properties for O83809

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 272 - 483 IPR002314
domain Anticodon-binding 495 - 582 IPR004154
domain Aminoacyl-tRNA synthetase, class II 216 - 488 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 118 - 169 IPR012947
domain Threonine-tRNA ligase catalytic core domain 192 - 493 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 493 - 577 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGLCVEENIT MLQKRSDTLD RLRHSLAHVM AEAVQALFPG TKLAVGPPID YGFYYDFSPP
70 80 90 100 110 120
RPLCDADLAP IEEKMRAILR AGCPFVKEVV SRPDALARFK DEPFKQELIE RISADDTLSL
130 140 150 160 170 180
YHSGAFTDLC RGPHVQSMRD INPHAFKLTS IAGAYWRGNE RGPQLTRIYG TAWESEEDLH
190 200 210 220 230 240
TYLRMQDEAK RRDHRKLGPA LGLFHLDEEN PGQVFWHPEG WTLYVAIQQY LRRVMHEDGY
250 260 270 280 290 300
AEVHTPFVMP QSLWERSGHW DKYRANMYLT EGEKRSFALK PMNCPGHVEI FKQKTRSYRD
310 320 330 340 350 360
LPLRLSEFGS CTRNEPSGSL HGVMRVRGFV QDDAHIFCTE AQIASEVTRF CRLLARVYAD
370 380 390 400 410 420
FGFAQEQIRV KFSTRPEQRI GDDATWDRAE RALAEACEAA GLSYEHAPGE GAFYGPKLEF
430 440 450 460 470 480
ALIDTLEREW QCGTIQVDYQ LPSCERLNAE YVGEDNQRHM PVILHRTVIG SLERFIGILI
490 500 510 520 530 540
EHYGGAFPPW LAPVQAVVIP VAPAFLEYAQ HVARELCARS LRVQADVSAE RMNAKIRTAQ
550 560 570 580 590
TQKVPYLLIV GERELRAQQV AVRPRTGPQH SMGLSAFSTF LLAKLETRAL HA