O83505

PR
Gene name
dnaG
Protein name
DNA primase
Names
Species
Treponema pallidum (strain Nichols)
KEGG Pathway
tpa:TP_0492
EC number
2.7.7.101: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O83505

Entry ID Method Resolution Chain Position Source
AF-O83505-F1 Predicted AlphaFoldDB

No variants for O83505

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O83505

No associated diseases with O83505

5 regional properties for O83505

Type Name Position InterPro Accession
domain Zinc finger, CHC2-type 5 - 99 IPR002694
domain TOPRIM domain 257 - 338 IPR006171
domain DNA primase, DnaG 3 - 413 IPR006295
domain DNA primase, catalytic core, N-terminal 126 - 249 IPR013264
domain Bacterial DnaG primase, TOPRIM domain 257 - 335 IPR034151

Functions

Description
EC Number 2.7.7.101 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.
primosome complex Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA primase activity Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARISAHVID AIADRVDLVS LVGNYTHLER RGDDWWGRCP FHHERTPSFH VVPDKKMYYC
70 80 90 100 110 120
FGCGVGGSTI KFFMEIEKID FHEAAVRLAK RAGIEMSFED GVHAPSAHAS FTMQLCEVYQ
130 140 150 160 170 180
RIAETFHHVL MHTAQGARAR AYLASRKVTD DSIRTFKLGY APPDPVWLFQ FLRHKGYSPE
190 200 210 220 230 240
FLARSGLFAK KSERIAVFSD RIMYPIADRY GQVIAFGARA LGTAPAKYLN TADMPQYKKG
250 260 270 280 290 300
EHLFAFHCAL SQMRKTRAAI ICEGYMDVIA FHQAQLTYAV APLGALLTKS QARLMRSFVD
310 320 330 340 350 360
RIYMCFDADG AGRAATYKAI LLCRSLGFEV RIVELNGGTD PAECACIEGE DALRKSVERS
370 380 390 400 410 420
TTDAQYLIRC ARHEHSHLGA DDTSRAVSFL FPYLSVLDSA IQREQVMQDI AMAFGIRIQA
430 440 450 460 470 480
VHADYLRYVS RTTQKGTTGN CVLSVQGTAI QVKEPATGVR TAQLRLVLAV VANPELFELL
490 500 510 520 530 540
RESVCADDFE DPMAKELFII LEECYRADTR ASPHVLSCCT TDELRKLVSE AIVCGEFSCN
550 560 570 580 590 600
APQIVRDGVA LVRRNRLLKE RESLVGRLRR FGDASSGEEC GSMQELMMEK QRVDEELERL
KGVRK