O83462
Gene name |
upp (TP_0448) |
Protein name |
Putative uracil phosphoribosyltransferase |
Names |
UMP pyrophosphorylase, UPRTase |
Species |
Treponema pallidum (strain Nichols) |
KEGG Pathway |
tpa:TP_0448 |
EC number |
2.4.2.9: Pentosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O83462
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O83462-F1 | Predicted | AlphaFoldDB |
No variants for O83462
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O83462 | |||||
No associated diseases with O83462
1 regional properties for O83462
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphoribosyltransferase domain | 163 - 282 | IPR000836 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.2.9 | Pentosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| uracil phosphoribosyltransferase activity | Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| UMP salvage | Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGQTARRVI | TEAKFLDDCL | TERDSYYLSK | LDELYSSAMS | SFAQFEDQQN | GARSARAEEN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IIATYDSIGN | LMQEICKELP | ALKVYSFETQ | RENHAEVSRV | VSKLRNIHTG | YSEFIYYTQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AFEMLFRLAY | GGSHEEHKTY | LITKTPVAFP | VQNYAVHKIA | NVDYKIENTV | MCVMLRGALL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PSMIVSKEIE | EYSSHGYVTP | FALFKIKRDD | LRDERDMQYV | FDLDKSYFSA | RELDGKDLVF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADPMNATGGS | LVTIVRYLQD | LGVKPKSISC | FHMISALKGA | IRVVRSLENC | TVYTLWMDPV |
| 310 | 320 | 330 | 340 | 350 | |
| LNARAYIMPG | LGDAGDRVNG | VDVEDYPRNI | IQLLADYGSN | ISGLYRSQLR | KIEETVLGSR |