O83460
Gene name |
ispG |
Protein name |
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) |
Names |
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase |
Species |
Treponema pallidum (strain Nichols) |
KEGG Pathway |
tpa:TP_0446 |
EC number |
1.17.7.3: With an iron-sulfur protein as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O83460
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O83460-F1 | Predicted | AlphaFoldDB |
No variants for O83460
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O83460 | |||||
No associated diseases with O83460
No regional properties for O83460
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O83460 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.17.7.3 | With an iron-sulfur protein as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity | Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. |
| iron ion binding | Binding to an iron (Fe) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. |
| terpenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSSAGVSPC | NSPYGSGLLD | VPLKLRPRAS | HYRARSLVIG | GKEHVRALPL | GGDAPIPIQT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MWKEPLIGAD | LQSIVDRLLE | LEQLGCDVVR | FAVPDRESAE | LFVALCARTR | MPLVADIHFD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YRLALRCMDG | PVAKVRINPG | NIGVRERVRA | VVEKARATGT | ALRIGVNTGS | LPGVVKRAVA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARYADGMQSV | NARAEALVQT | AFAEAAYLDQ | LHFDRVVLSL | KASTVAETVR | ANELFAQQSD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IPLHLGVTEA | GPLVSGIVKS | TLAFSQLLSR | NIGATVRVSL | SDSMEHEVLA | AREILAECGK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RAGGVRLVSC | PRCGRIGFDV | HAFVRRWQKE | LFSLKKDITV | AVMGCVVNGP | GEGKHADLGI |
| 370 | 380 | 390 | 400 | ||
| SGAEDSVIFF | KRGKIVRRIQ | VRDLCADERT | RIIDAAFKEE | LSSL |