O83270

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Treponema pallidum (strain Nichols)
KEGG Pathway
tpa:TP_0242
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

273-348 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O83270

Entry ID Method Resolution Chain Position Source
AF-O83270-F1 Predicted AlphaFoldDB

No variants for O83270

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O83270

No associated diseases with O83270

7 regional properties for O83270

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 333 - 384 IPR000722-1
domain RNA polymerase, alpha subunit 383 - 474 IPR000722-2
domain RNA polymerase, N-terminal 224 - 503 IPR006592
domain RNA polymerase Rpb1, domain 3 478 - 622 IPR007066
domain RNA polymerase Rpb1, domain 1 6 - 331 IPR007080
domain RNA polymerase Rpb1, domain 5 733 - 1319 IPR007081
domain RNA polymerase Rpb1, domain 4 651 - 725 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKDIRDFDSL QIKLASPDTI RAWSYGEVKK PETINYRTLR PEREGLFCER IFGTTKEWEC
70 80 90 100 110 120
FCGKFKSIRY RGVICDRCGV EVTHFKVRRE RMGHIELATP VSHIWYYRCV PSRMGLLLDL
130 140 150 160 170 180
QVIALRSVLY YEKYIVIEPG DTDLKKNQLL TETEYNDAQE RYGGGFTAGM GAEAIRTLLQ
190 200 210 220 230 240
NLDLDALVAQ LREKMMEKGA KSDKRLLRRI EIVENFRVSG NKPEWMILSV IPVIPPDLRP
250 260 270 280 290 300
MVQLDGGRFA TSDLNDLYRR VIHRNSRLIR LMELKAPDII IRNEKRMLQE AVDALFDNSK
310 320 330 340 350 360
RKPAIKGASN RPLKSISDML KGKQGRFRQN LLGKRVDYSG RSVIVVGPEL KLWQCGLPTK
370 380 390 400 410 420
MALELFKPFI MKKLVEKEIV SNIKKAKMLV EQESPKVFSV LDEVVKEHPV MLNRAPTLHR
430 440 450 460 470 480
LGIQAFEPVL VEGKAIRLHP LVCKPFNADF DGDQMAVHVP LTQAAQMECW TLMLSNRNLL
490 500 510 520 530 540
DPANGRTIVY PSQDMVLGLY YLTKERSLPE GARPRRFSSV EEVMMAAEKG VIGWQDQIQV
550 560 570 580 590 600
RYHKCDGQLV VTTAGRLVLN EEVPAEIPFV NETLDDKRIR KLIERVFKRQ DSWLAVQMLD
610 620 630 640 650 660
ALKTIGYTYA TFFGATLSMD DIIVPEQKVQ MLEKANKEVL AIASQYRGGH ITQEERYNRV
670 680 690 700 710 720
VEVWSKTSEE LTSLMMETLE RDKDGFNTIY MMATSGARGS RNQIRQLAGM RGLMAKPSGD
730 740 750 760 770 780
IIELPIRSNF KEGLNVIEFF ISTNGARKGL ADTALKTADA GYLTRRLVDI AQDVVVNEED
790 800 810 820 830 840
CGTINGIEYR AVKSGDEIIE SLAERIVGKY TLERVEHPIT HELLLDVNEY IDDERAEKVE
850 860 870 880 890 900
EAGVESVKLR TVLTCESKRG VCVCCYGRNL ARNKIVEIGE AVGIVAAQSI GQPGTQLTMR
910 920 930 940 950 960
TFHVGGTASS TTEENRITFK YPILVKSIEG VHVKMEDGSQ LFTRRGTLFF HKTLAEYQLQ
970 980 990 1000 1010 1020
EGDSVQVRDR ARVLKDEVLY HTTDGQTVYA SVSGFARIID RTVYLVGPEQ KTEIRNGSNV
1030 1040 1050 1060 1070 1080
VIKADEYVPP GKTVATFDPF TEPILAEQDG FVRYEDIILG STLIEEVNTE TGMVERRITT
1090 1100 1110 1120 1130 1140
LKTGIQLQPR VFISDESGNA LGSYYLPEEA RLMVEEGAQV KAGTVIVKLA KAIQKTSDIT
1150 1160 1170 1180 1190 1200
GGLPRVSELF EARRPKNAAV LAQISGVVSF KGLFKGKRIV VVRDHYGKEY KHLVSMSRQL
1210 1220 1230 1240 1250 1260
LVRDGDTVEA GERLCDGCFD PHDILAILGE NALQNYLMNE IRDVYRVQGV SINDQHIGLV
1270 1280 1290 1300 1310 1320
VRQMLRKTEV VSVGDTRFIY GQQVDKYRFH EENRRVEAEG GQPAVARPMF QGITKAALNI
1330 1340 1350 1360 1370 1380
DSFISAASFQ ETNKVLTNAA IAGSVDDLCG LKENVIIGHL IPAGTGMRRY RQVKLFDKNK
1390 1400 1410
RDLDVQMEEV IRRRKLEEEA LAQAVAGMEG EPEGEA