O83059

PR
Gene name
pheT
Protein name
Phenylalanine--tRNA ligase beta subunit
Names
Phenylalanyl-tRNA synthetase beta subunit, PheRS
Species
Treponema pallidum (strain Nichols)
KEGG Pathway
tpa:TP_0015
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O83059

Entry ID Method Resolution Chain Position Source
AF-O83059-F1 Predicted AlphaFoldDB

No variants for O83059

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O83059

No associated diseases with O83059

6 regional properties for O83059

Type Name Position InterPro Accession
domain tRNA-binding domain 38 - 148 IPR002547
domain Ferrodoxin-fold anticodon-binding domain 703 - 796 IPR005121
domain B3/B4 tRNA-binding domain 212 - 385 IPR005146
domain tRNA synthetase, B5-domain 400 - 475 IPR005147
domain Phenylalanly tRNA synthetase, tRNA-binding-domain 60 - 147 IPR033714
domain Phenylalanyl tRNA synthetase beta chain, core domain 474 - 689 IPR041616

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKISIHEAL FFELLGERCD DDTLERRLRS AKAELECSSF SVREDKEGGS LSPGGEVCDP
70 80 90 100 110 120
VQRTRGQASC VREGAFDARL LKIELNDTNR PDLWSTAGLA RLLRVHAGGA SRAAQYRAFL
130 140 150 160 170 180
SDRCTVRDSY GRCVVVDARL QTIRPFIAGF VARGTGLSEV RLWDLIQTQE RLASNFGRRR
190 200 210 220 230 240
CTLSLGCYRA QDICWPLAYR AVLLAEVSFT PLGMSMPLSG EQILTQHPKG REYGHLLKDY
250 260 270 280 290 300
SFVPLLVDAR GEVLSLIPIT NSASLGAVVT GDTELFIECS GTDMCAVLVA VNSLACDLSD
310 320 330 340 350 360
MGMQIEPVQI TYSFDTPWGR SVTTPFYFQE KREVAHEQID RLLGMPLPVA DITEAFARMD
370 380 390 400 410 420
CAVQVKQGTY VVEPAAYRND FLHAVDLIEE VMLGRTLDRF SPQVPCSFTV GRLSDLTLLT
430 440 450 460 470 480
RKIKHLLVGF GYQEMIFHYL GSAREFCTRM RCTADDLIEI ENPLTESYRF VRRSIIPCLL
490 500 510 520 530 540
SAELKSAHAL YPHRIFEIGK VAFCSPHGEH GTCTQQSLGF LNASQEASYN EVASLVSGLL
550 560 570 580 590 600
YCLKLPYQVE EAQDPRFVLG RQASICVHGS RVGIFGEIHP QVLSNWDIRM PCFAGELDVG
ALLP