AiPD: Autoinhibited Protein Database

Gene name	ALG3 (At2g47760, F17A22.15)
Protein name	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Names	Alpha-1,3-mannosyltransferase ALG3, Asparagine-linked glycosylation protein 3, AtALG3, Not56-like protein
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G47760
EC number	2.4.1.258: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O82244-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH01999803	6	S>T	No	1000Genomes
ENSVATH01999802	17	R>W	No	1000Genomes
ENSVATH05736489	28	F>L	No	1000Genomes
ENSVATH13670802	48	A>S	No	1000Genomes
ENSVATH05736484	100	A>T	No	1000Genomes
tmp_2_19567717_T_A	110	Y>F	No	1000Genomes
ENSVATH01999797	129	I>F	No	1000Genomes
tmp_2_19567230_T_A	178	Y>F	No	1000Genomes
ENSVATH01999795	178	Y>H	No	1000Genomes
tmp_2_19567085_T_G	204	T>P	No	1000Genomes
ENSVATH13670798	208	L>P	No	1000Genomes
ENSVATH13670797	228	V>L	No	1000Genomes
tmp_2_19566708_G_C	235	P>A	No	1000Genomes
ENSVATH05736467	245	I>V	No	1000Genomes
tmp_2_19566475_G_C	281	L>V	No	1000Genomes
ENSVATH05736465	294	Y>N	No	1000Genomes
ENSVATH14625461	306	F>L	No	1000Genomes
ENSVATH01999792	311	H>R	No	1000Genomes
ENSVATH05736461	315	T>S	No	1000Genomes
tmp_2_19566272_A_G	319	S>P	No	1000Genomes
ENSVATH01999791	329	R>Q	No	1000Genomes
tmp_2_19566235_A_G	331	I>T	No	1000Genomes
tmp_2_19566134_A_T	341	F>I	No	1000Genomes
ENSVATH05736457	374	P>S	No	1000Genomes
ENSVATH05736456	384	F>L	No	1000Genomes
ENSVATH05736455	388	E>D	No	1000Genomes
ENSVATH01999788	422	D>N	No	1000Genomes
ENSVATH13670776	429	H>D	No	1000Genomes

Type	Name	Position	InterPro Accession
conserved_site	Aminoacyl-tRNA synthetase, class I, conserved site	39 - 49	IPR001412
domain	RNA-binding S4 domain	353 - 414	IPR002942

		Description
EC Number	2.4.1.258	Hexosyltransferases
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
alpha-1,3-mannosyltransferase activity	Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

Name	Definition
protein glycosylation	A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins