AiPD: Autoinhibited Protein Database

Gene name	ITPK2 (At4g33770, T16L1.260)
Protein name	Inositol-tetrakisphosphate 1-kinase 2
Names	Inositol 1,3,4-trisphosphate 5/6-kinase 2, AtItpk-2, Inositol-triphosphate 5/6-kinase 2, Ins(1,3,4)P(3) 5/6-kinase 2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G33770
EC number	2.7.1.134: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

15-100 (Predicted disordered autoinhibitory region) PR

15-100 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O81893-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH12373095	12	T>A	No	1000Genomes
tmp_4_16196200_G_C	15	L>V	No	1000Genomes
tmp_4_16196196_T_C	16	N>S	No	1000Genomes
ENSVATH02954230	27	V>F	No	1000Genomes
ENSVATH02954230	27	V>L	No	1000Genomes
ENSVATH00550902	40	E>Q	No	1000Genomes
ENSVATH06819248	51	E>G	No	1000Genomes
ENSVATH02954229	52	Q>E	No	1000Genomes
ENSVATH14332303	62	N>D	No	1000Genomes
ENSVATH00550901	62	N>S	No	1000Genomes
ENSVATH06819247	66	P>S	No	1000Genomes
ENSVATH06819246	75	L>Q	No	1000Genomes
ENSVATH02954228	80	K>Q	No	1000Genomes
tmp_4_16195998_A_T	82	V>D	No	1000Genomes
tmp_4_16195999_C_T	82	V>I	No	1000Genomes
tmp_4_16195172_A_T	116	L>M	No	1000Genomes
ENSVATH02954226	137	E>D	No	1000Genomes
ENSVATH00550897	172	Q>H	No	1000Genomes
tmp_4_16194679_A_T	180	S>T	No	1000Genomes
tmp_4_16194566_G_A	186	L>F	No	1000Genomes
ENSVATH06819234	204	A>G	No	1000Genomes
ENSVATH06819233	206	V>A	No	1000Genomes
tmp_4_16194135_T_C	269	K>R	No	1000Genomes
ENSVATH06819225	354	I>V	No	1000Genomes
ENSVATH02954218	384	Y>D	No	1000Genomes
tmp_4_16193608_T_G	386	K>T	No	1000Genomes
tmp_4_16193593_T_A	391	K>I	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain	184 - 377	IPR040464
domain	Inositol-tetrakisphosphate 1-kinase, N-terminal	82 - 161	IPR041429

		Description
EC Number	2.7.1.134	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
inositol tetrakisphosphate 1-kinase activity	Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.
inositol-1,3,4-trisphosphate 5-kinase activity	Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
inositol-1,3,4-trisphosphate 6-kinase activity	Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).
magnesium ion binding	Binding to a magnesium (Mg) ion.

Name	Definition
inositol phosphorylation	The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms.
inositol trisphosphate metabolic process	The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
seed coat development	The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins