O80763

PR
Gene name
At1g60420 (T13D8.29)
Protein name
Probable nucleoredoxin 1
Names
AtNrx1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G60420
EC number
1.8.1.8: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O80763

Entry ID Method Resolution Chain Position Source
1V5N NMR - A 476-551 PDB
AF-O80763-F1 Predicted AlphaFoldDB

77 variants for O80763

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_22261985_A_G 3 E>G No 1000Genomes
tmp_1_22261984_G_C 3 E>Q No 1000Genomes
ENSVATH05010691 13 A>G No 1000Genomes
ENSVATH00107784 14 Q>E No 1000Genomes
tmp_1_22262021_A_G 15 D>G No 1000Genomes
ENSVATH05010692 17 H>Q No 1000Genomes
ENSVATH13667795 24 A>V No 1000Genomes
ENSVATH13667796 26 D>N No 1000Genomes
ENSVATH05010694 32 D>N No 1000Genomes
ENSVATH05010694 32 D>Y No 1000Genomes
ENSVATH05010698 42 L>F No 1000Genomes
ENSVATH01411300 42 L>I No 1000Genomes
tmp_1_22262502_G_A 77 G>D No 1000Genomes
ENSVATH01411302 97 R>S No 1000Genomes
ENSVATH05010700 110 E>K No 1000Genomes
ENSVATH14367201 111 T>S No 1000Genomes
tmp_1_22262613_G_A 114 R>H No 1000Genomes
ENSVATH13667817 115 L>V No 1000Genomes
ENSVATH13667818 121 V>L No 1000Genomes
tmp_1_22262637_G_T 122 R>M No 1000Genomes
tmp_1_22262676_A_T 135 K>I No 1000Genomes
ENSVATH01411303 144 V>I No 1000Genomes
tmp_1_22262714_T_C 148 Y>H No 1000Genomes
ENSVATH13667819 150 A>P No 1000Genomes
tmp_1_22262746_G_T 158 E>D No 1000Genomes
ENSVATH05010701 162 E>D No 1000Genomes
tmp_1_22262759_A_G 163 I>V No 1000Genomes
tmp_1_22262775_A_C 168 D>A No 1000Genomes
ENSVATH00107788 173 G>E No 1000Genomes
ENSVATH00107789 177 R>T No 1000Genomes
ENSVATH13667820 190 S>L No 1000Genomes
ENSVATH00107791 192 D>E No 1000Genomes
tmp_1_22262854_C_G 194 N>K No 1000Genomes
ENSVATH05010709 197 P>S No 1000Genomes
ENSVATH00107793 216 R>K No 1000Genomes
ENSVATH01411315 221 L>F No 1000Genomes
tmp_1_22263081_C_T 222 T>I No 1000Genomes
tmp_1_22263104_A_G 230 T>A No 1000Genomes
tmp_1_22263120_A_G 235 N>S No 1000Genomes
tmp_1_22263124_G_T 236 K>N No 1000Genomes
tmp_1_22263127_G_T 237 E>D No 1000Genomes
ENSVATH14367203 242 V>L No 1000Genomes
tmp_1_22263171_C_G 252 S>C No 1000Genomes
tmp_1_22263176_A_C 254 N>H No 1000Genomes
ENSVATH05010711 255 Q>K No 1000Genomes
ENSVATH05010712 255 Q>L No 1000Genomes
tmp_1_22263302_A_T 296 T>S No 1000Genomes
ENSVATH14367215 297 R>C No 1000Genomes
ENSVATH14367215 297 R>S No 1000Genomes
ENSVATH05010716 316 T>P No 1000Genomes
tmp_1_22263370_G_T 318 E>D No 1000Genomes
ENSVATH01411319 326 L>I No 1000Genomes
ENSVATH05010717 327 E>K No 1000Genomes
ENSVATH01411320 328 K>N No 1000Genomes
ENSVATH14367216 348 V>I No 1000Genomes
tmp_1_22263582_C_G 359 S>W No 1000Genomes
ENSVATH05010726 365 T>N No 1000Genomes
tmp_1_22263611_T_A 369 Y>N No 1000Genomes
tmp_1_22263645_C_T 380 A>V No 1000Genomes
ENSVATH05010727 388 V>L No 1000Genomes
tmp_1_22263690_G_A 395 R>Q No 1000Genomes
tmp_1_22263696_A_C 397 E>A No 1000Genomes
ENSVATH05010728 409 D>N No 1000Genomes
ENSVATH00107800 455 Q>K No 1000Genomes
ENSVATH01411324 455 Q>L No 1000Genomes
tmp_1_22263902_G_T 466 V>L No 1000Genomes
tmp_1_22263920_G_A 472 A>T No 1000Genomes
ENSVATH01411325 485 A>V No 1000Genomes
ENSVATH00107801 490 I>M No 1000Genomes
ENSVATH00107802 493 D>E No 1000Genomes
tmp_1_22263988_G_T 494 W>C No 1000Genomes
ENSVATH00107803 498 V>L No 1000Genomes
tmp_1_22264073_G_C 523 E>Q No 1000Genomes
ENSVATH00107804 534 E>V No 1000Genomes
ENSVATH05010732 554 D>E No 1000Genomes
ENSVATH01411327 559 V>D No 1000Genomes
tmp_1_22264224_A_C 573 N>T No 1000Genomes

No associated diseases with O80763

9 regional properties for O80763

Type Name Position InterPro Accession
domain DC1 502 - 544 IPR004146
domain Thioredoxin-like fold 43 - 135 IPR012336-1
domain Thioredoxin-like fold 203 - 295 IPR012336-2
domain Thioredoxin-like fold 363 - 455 IPR012336-3
domain Thioredoxin domain 18 - 172 IPR013766-1
domain Thioredoxin domain 325 - 485 IPR013766-2
conserved_site Thioredoxin, conserved site 367 - 385 IPR017937
domain TryX and NRX, thioredoxin domain 26 - 155 IPR045870-1
domain TryX and NRX, thioredoxin domain 346 - 475 IPR045870-2

Functions

Description
EC Number 1.8.1.8 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
thioredoxin-disulfide reductase activity Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.

3 GO annotations of biological process

Name Definition
pollen tube growth Growth of pollen via tip extension of the intine wall.
pollen tube guidance The process in which the growth of pollen tube is directed towards the female gametophyte.
regulation of pollen tube growth Any process that modulates the frequency, rate or extent of pollen tube growth.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAETSKQVNG DDAQDLHSLL SSPARDFLVR NDGEQVKVDS LLGKKIGLYF SAAWCGPCQR
70 80 90 100 110 120
FTPQLVEVYN ELSSKVGFEI VFVSGDEDEE SFGDYFRKMP WLAVPFTDSE TRDRLDELFK
130 140 150 160 170 180
VRGIPNLVMV DDHGKLVNEN GVGVIRSYGA DAYPFTPEKM KEIKEDEDRA RRGQTLRSVL
190 200 210 220 230 240
VTPSRDFVIS PDGNKVPVSE LEGKTIGLLF SVASYRKCTE LTPKLVEFYT KLKENKEDFE
250 260 270 280 290 300
IVLISLEDDE ESFNQDFKTK PWLALPFNDK SGSKLARHFM LSTLPTLVIL GPDGKTRHSN
310 320 330 340 350 360
VAEAIDDYGV LAYPFTPEKF QELKELEKAK VEAQTLESLL VSGDLNYVLG KDGAKVLVSD
370 380 390 400 410 420
LVGKTILMYF SAHWCPPCRA FTPKLVEVYK QIKERNEAFE LIFISSDRDQ ESFDEYYSQM
430 440 450 460 470 480
PWLALPFGDP RKASLAKTFK VGGIPMLAAL GPTGQTVTKE ARDLVVAHGA DAYPFTEERL
490 500 510 520 530 540
KEIEAKYDEI AKDWPKKVKH VLHEEHELEL TRVQVYTCDK CEEEGTIWSY HCDECDFDLH
550 560 570
AKCALNEDTK ENGDEAVKVG GDESKDGWVC EGNVCTKA