O80632
Gene name |
MTP11 (At2g39450, F12L6.11) |
Protein name |
Metal tolerance protein 11 |
Names |
AtMTP11 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G39450 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O80632
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O80632-F1 | Predicted | AlphaFoldDB |
15 variants for O80632
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14598677 | 5 | A>G | No | 1000Genomes | |
| ENSVATH13583874 | 31 | D>H | No | 1000Genomes | |
| tmp_2_16473624_C_G | 38 | E>Q | No | 1000Genomes | |
| ENSVATH13583873 | 44 | S>F | No | 1000Genomes | |
| ENSVATH13583867 | 94 | E>D | No | 1000Genomes | |
| ENSVATH00265941 | 104 | L>F | No | 1000Genomes | |
| tmp_2_16472825_A_G | 154 | F>S | No | 1000Genomes | |
| tmp_2_16472488_A_C | 200 | S>A | No | 1000Genomes | |
| tmp_2_16472368_C_T | 213 | S>N | No | 1000Genomes | |
| ENSVATH13583853 | 224 | L>S | No | 1000Genomes | |
| tmp_2_16472222_C_G | 262 | V>L | No | 1000Genomes | |
| tmp_2_16472206_T_A | 267 | Y>F | No | 1000Genomes | |
| ENSVATH05684413 | 279 | I>V | No | 1000Genomes | |
| tmp_2_16472040_T_A | 297 | N>Y | No | 1000Genomes | |
| ENSVATH01968268 | 393 | H>Q | No | 1000Genomes |
No associated diseases with O80632
6 regional properties for O80632
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 269 - 424 | IPR001650 |
| domain | AAA+ ATPase domain | 46 - 331 | IPR003593 |
| domain | DEAD/DEAH box helicase domain | 34 - 216 | IPR011545 |
| domain | DEAD/H associated | 641 - 828 | IPR013701 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 29 - 250 | IPR014001 |
| domain | Helicase Lhr-like, winged helix domain | 421 - 565 | IPR045628 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cation transmembrane transporter activity | Enables the transfer of cation from one side of a membrane to the other. |
| manganese ion transmembrane transporter activity | Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. |
| manganese:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular manganese ion homeostasis | Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell. |
| response to copper ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. |
| response to manganese ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9LDU0 | MTP7 | Metal tolerance protein 7 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVEPASPDSD | EGISLLEFHG | NGDRSWQLNF | DDFQVSPEHK | EKKSPSKLHN | CLGCLGPEDN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VADYYQQQVE | MLEGFTEMDE | LAERGFVPGM | SKEEQDNLAK | SETLAIRISN | IANMLLFAAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VYASVTSGSL | AIIASTLDSL | LDLLSGFILW | FTAFSMQTPN | PYQYPIGKKR | MQPLGILVFA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVMATLGLQI | ILESLRTMLS | SHKEFNLTKE | QESWVVGIML | SVTLVKLLLV | LYCRSFTNEI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKAYAQDHFF | DVITNIIGLI | AVILANYIDY | WIDPVGAIIL | ALYTIRTWSM | TVLENVNSLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKSARPEYLQ | KLTYLCWNHH | KAIRHIDTVR | AYTFGSHYFV | EVDIVLPADM | PLQVAHDIGE |
| 370 | 380 | 390 | |||
| SLQEKLELLE | EIERAFVHLD | YEYTHKPEHA | RSHC |