O80450
Gene name |
GT-3B (GT1L, GT3B, At2g38250, F16M14.18) |
Protein name |
Trihelix transcription factor GT-3b |
Names |
Transcription factor GT-1-like, Trihelix DNA-binding protein GT-3b |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G38250 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O80450
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O80450-F1 | Predicted | AlphaFoldDB |
25 variants for O80450
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_16018434_G_C | 17 | K>N | No | 1000Genomes | |
| tmp_2_16018456_C_G | 25 | Q>E | No | 1000Genomes | |
| tmp_2_16018490_G_T | 36 | G>V | No | 1000Genomes | |
| ENSVATH13570925 | 86 | S>I | No | 1000Genomes | |
| tmp_2_16018979_C_T | 117 | P>S | No | 1000Genomes | |
| ENSVATH14595450 | 118 | F>L | No | 1000Genomes | |
| tmp_2_16018988_G_A | 120 | D>N | No | 1000Genomes | |
| ENSVATH13570931 | 122 | M>L | No | 1000Genomes | |
| tmp_2_16019057_G_C | 143 | G>R | No | 1000Genomes | |
| tmp_2_16019073_C_A | 148 | A>E | No | 1000Genomes | |
| tmp_2_16019111_G_C | 161 | E>Q | No | 1000Genomes | |
| ENSVATH05676730 | 162 | N>T | No | 1000Genomes | |
| ENSVATH05676731 | 163 | V>L | No | 1000Genomes | |
| ENSVATH05676732 | 180 | K>N | No | 1000Genomes | |
| ENSVATH05676733 | 181 | K>T | No | 1000Genomes | |
| ENSVATH05676737 | 216 | S>G | No | 1000Genomes | |
| tmp_2_16019278_C_T,A | 216 | S>R | No | 1000Genomes | |
| ENSVATH05676738 | 224 | A>T | No | 1000Genomes | |
| ENSVATH05676740 | 231 | E>D | No | 1000Genomes | |
| tmp_2_16019327_G_A | 233 | E>K | No | 1000Genomes | |
| tmp_2_16019370_G_A | 247 | R>K | No | 1000Genomes | |
| ENSVATH01964279 | 252 | R>L | No | 1000Genomes | |
| ENSVATH01964279 | 252 | R>Q | No | 1000Genomes | |
| ENSVATH05676741 | 278 | A>E | No | 1000Genomes | |
| tmp_2_16019488_T_A | 286 | D>E | No | 1000Genomes |
No associated diseases with O80450
No regional properties for O80450
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O80450 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDGHQHHHLH | QLQYLNKHHL | HTQSQTPEIA | SPVAVGDRFP | QWSVEETKEL | IGIRGELDQT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FMETKRNKLL | WEVISNKMRD | KSFPRSPEQC | KCKWKNLVTR | FKGCETMEAE | TARQQFPFYD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMQNIFTTRM | QRMLWAESEG | GGGGTSGAAR | KREYSSDEEE | ENVNEELVDV | SNDPKILNPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNIAKKRKGG | SNSSNSNNGV | REVLEEFMRH | QVRMESEWRE | GWEAREKERA | EKEEEWRRKM |
| 250 | 260 | 270 | 280 | ||
| EELEKERLAM | ERMWRDREEQ | RRSREEMRAE | KRDSLINALL | AKLTRDGSL |