AiPD: Autoinhibited Protein Database

Gene name	FPG1 (FPG2, At1g52500, F6D8.28)
Protein name	Formamidopyrimidine-DNA glycosylase
Names	Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase FPG1, Formamidopyrimidine-DNA glycosylase 1, AtFPG-1, Formamidopyrimidine-DNA glycosylase 2, AtFPG-2, Protein MutM homolog 1, AtMMH-1, Protein MutM homolog 2, AtMMH-2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G52500
EC number	3.2.2.23: Hydrolyzing N-glycosyl compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

120-191 (Predicted disordered autoinhibitory region) PR

120-191 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3TWK	X-ray	230 A	A/B	1-281	PDB
3TWL	X-ray	170 A	A	1-304	PDB
3TWM	X-ray	280 A	A/B	1-304	PDB
AF-O80358-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13533785	13	A>V	No	1000Genomes
tmp_1_19560169_T_C	43	F>L	No	1000Genomes
tmp_1_19560224_A_C	61	N>T	No	1000Genomes
tmp_1_19560707_T_C	82	I>T	No	1000Genomes
tmp_1_19560743_G_C	94	R>T	No	1000Genomes
ENSVATH04945220	162	E>K	No	1000Genomes
ENSVATH13533823	164	L>F	No	1000Genomes
ENSVATH13533824	165	A>T	No	1000Genomes
tmp_1_19561248_C_T	173	P>S	No	1000Genomes
tmp_1_19561708_A_C	203	T>P	No	1000Genomes
tmp_1_19561734_A_C	211	Q>H	No	1000Genomes
ENSVATH00094502	216	H>Y	No	1000Genomes
tmp_1_19561751_C_A	217	T>K	No	1000Genomes
ENSVATH04945226	219	I>V	No	1000Genomes
tmp_1_19561759_A_G	220	K>E	No	1000Genomes
tmp_1_19561760_A_T	220	K>I	No	1000Genomes
ENSVATH01356803	239	Y>N	No	1000Genomes
tmp_1_19562108_G_A	240	W>*	No	1000Genomes
tmp_1_19562528_C_G	282	D>E	No	1000Genomes
tmp_1_19562526_G_A	282	D>N	No	1000Genomes
tmp_1_19562530_C_T	283	A>V	No	1000Genomes
ENSVATH04945239	291	P>L	No	1000Genomes
ENSVATH04945241	309	E>A	No	1000Genomes
ENSVATH04945242	315	E>K	No	1000Genomes
ENSVATH01356805	321	S>L	No	1000Genomes
ENSVATH04945243	323	K>N	No	1000Genomes
tmp_1_19562685_C_T	335	P>S	No	1000Genomes
tmp_1_19562689_C_G	336	A>G	No	1000Genomes
tmp_1_19562692_C_T	337	S>L	No	1000Genomes
ENSVATH13533897	341	T>I	No	1000Genomes
tmp_1_19562706_G_C	342	E>Q	No	1000Genomes
ENSVATH14298791	346	D>H	No	1000Genomes
tmp_1_19562731_A_G	350	D>G	No	1000Genomes
tmp_1_19562736_G_A	352	E>K	No	1000Genomes
ENSVATH13533898	369	I>M	No	1000Genomes
ENSVATH04945244	372	K>M	No	1000Genomes
ENSVATH01356806	385	P>L	No	1000Genomes
tmp_1_19562847_A_G	389	K>E	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O80358

		Description
EC Number	3.2.2.23	Hydrolyzing N-glycosyl compounds
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
damaged DNA binding	Binding to damaged DNA.
DNA N-glycosylase activity	Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
DNA-(apurinic or apyrimidinic site) endonuclease activity	Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
oxidized purine nucleobase lesion DNA N-glycosylase activity	Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
base-excision repair	In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins