O77506

PR
Gene name
LASP1
Protein name
LIM and SH3 domain protein 1
Names
LASP-1, 40 kDa phosphoprotein, pp40
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009568
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-229 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O77506

Entry ID Method Resolution Chain Position Source
AF-O77506-F1 Predicted AlphaFoldDB

No variants for O77506

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O77506

No associated diseases with O77506

4 regional properties for O77506

Type Name Position InterPro Accession
domain Helix-hairpin-helix DNA-binding motif, class 1 71 - 90 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 106 - 125 IPR003583-2
domain Holliday junction DNA helicase RuvA, C-terminal 158 - 200 IPR011114
domain DNA helicase, Holliday junction RuvA type, domain I, bacterial 1 - 60 IPR013849

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cell cortex
  • Cytoplasm, cytoskeleton
  • Associated with the F-actin rich cortical cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

2 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
70 80 90 100 110 120
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGRGFSV VADTPELQRI KKTQDQISNI
130 140 150 160 170 180
KYHEEFEKSR MGPSGGEGAE PERRDSQDSS NYRRPPEQQQ PPQPHHIPTS TPAYQQPQPQ
190 200 210 220 230 240
QVAQSYGYKE PAAPVSTQRG APGGGGKRYR AVFDYSAADE DEVSFQDGDT IVNVQQIDDG
250 260
WMYGTVERTG DTGMLPANYV EAI