O77410
Gene name |
eIF3e |
Protein name |
Eukaryotic translation initiation factor 3 subunit E |
Names |
eIF3e, Eukaryotic translation initiation factor 3 subunit 6 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG9677 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O77410
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O77410-F1 | Predicted | AlphaFoldDB |
No variants for O77410
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O77410 | |||||
No associated diseases with O77410
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| eukaryotic 43S preinitiation complex | A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 3 complex | A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. |
| eukaryotic translation initiation factor 3 complex, eIF3e | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| formation of cytoplasmic translation initiation complex | Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2F5R8 | eIF3-S6 | Eukaryotic translation initiation factor 3 subunit E | Bombyx mori (Silk moth) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANFDLTRIN | CQFLDRHLTF | PLLEFLCGKE | IYNQQELLEY | ILETVNKTNM | IDYTMDTRKR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNLSQEMPEE | LVQRKAEVLA | TLKQLQNEVA | PIMKATDILK | NGESMKDSKT | FVNALQKDYN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKVEHLESAY | KLAKYLYECG | NYQESTSYLY | FCLIVMSPND | KNYLNVLWGK | LAAEILTLNW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NTALEDLTRL | RDYIDNANFS | TIQALQQRTW | LIHWSVLVFF | NHPKGRDLII | EMFLYKPLYL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NAIQTMCPHI | MRYLATAVVI | NRTRRNALKD | LIKVIQQESY | TYRDPITEFL | ECLYVNFDFE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GARLKLHECQ | TVILNDFFIV | ACLNEFVEDA | RLMIFETFCR | IHQCITISML | ADKLNMKPNE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AECWIVNLIR | NARLNAKIDS | KLGHVVMGTQ | PLSPYQQLVE | KIDSLSMRSE | HLAGLIERKS |
| 430 | |||||
| KQKQNQESAD | SWKYY |